Topological repulsion between polymer globules

Jeffrey Chuang, Alexander Yu Grosberg, Toyoichi Tanaka

    Research output: Contribution to journalArticlepeer-review


    The work is motivated by the experimental observation of B. Chu et al. [Macromolecules 28, 180 (1995)] which suggests that, while polymer globules in dilute solution in poor solvent are supposed to be very sticky, in actuality they collide many hundreds of times before merging and before aggregation starts. We argue that this slow-down is caused by an "entanglement force" which is operational on the prereptational time scale. This force arises from the fact that two touching globules cannot enjoy the mixing entropy gain expected in equilibrium until after they explore all conformations, including entangled ones. We report a molecular dynamics simulation in which we were able to measure the entanglement force as a function of distance. The important conclusion we can formulate so far is qualitative; the entanglement force exists and is sufficient to explain the observed slow-down of aggregation.

    Original languageEnglish (US)
    Pages (from-to)6434-6442
    Number of pages9
    JournalJournal of Chemical Physics
    Issue number14
    StatePublished - Apr 8 2000

    ASJC Scopus subject areas

    • General Physics and Astronomy
    • Physical and Theoretical Chemistry


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