Total hemoglobin changes in the breast tumors of patients undergoing neoadjuvant chemotherapy: A longitudinal analysis

Mirella L. Altoe, Alessandro Marone, Hyun K. Kim, Hua Guo, Haninna Hibshoosh, Mariella Tejada, Katherine D. Crew, Melissa K. Accordino, Meghna S. Trivedi, Kevin Kalinsky, Dawn L. Hershman, Andreas H. Hielscher

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Optical imaging techniques have emerged as a possible alternative to predict pathological complete response (pCR) in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). Our team developed a so-called diffuse optical tomographic breast imaging system (DOTBIS) which does not require the use of contrast agents or compression and enables imaging of the whole breast volume using low intensity near infrared light capable to measure tissue concentration of total hemoglobin (ctTHb). In this retrospective study, we evaluated 55 stage II-III BC patients in the neoadjuvant setting who received weekly paclitaxel x 12, followed by dose-dense adriamycin/cyclophosphamide every 2 weeks x 4. DOTBIS images were acquired from the patient whole breast volume at 6 different time points: at baseline (TP0); two weeks after the first taxane infusion (TP1); after four infusions of taxane (TP2); at the end of the taxane regimen and before starting AC cycle (TP3); after two AC infusions (TP4); and at the end of NAC and before surgery (TP5). In order to evaluate whether pCR status influences the change of ctTHb over time, we designed a multilevel mixed-effect model. pCR was defined as no invasive tumor cells from the breast and axillary tissue at surgery (ypT0 ypN0). Changes in ctTHb levels compared to baseline (TP0) values were statistically significant different between pCR (n = 20) and non-pCR (n=35) at all time points except at TP1 and at the end of the taxane cycle (TP3).

    Original languageEnglish (US)
    Title of host publicationOptical Tomography and Spectroscopy of Tissue XIV
    EditorsSergio Fantini, Paola Taroni
    PublisherSPIE
    ISBN (Electronic)9781510641136
    DOIs
    StatePublished - 2021
    EventOptical Tomography and Spectroscopy of Tissue XIV 2021 - Virtual, Online, United States
    Duration: Mar 6 2021Mar 11 2021

    Publication series

    NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume11639
    ISSN (Print)1605-7422

    Conference

    ConferenceOptical Tomography and Spectroscopy of Tissue XIV 2021
    Country/TerritoryUnited States
    CityVirtual, Online
    Period3/6/213/11/21

    Keywords

    • Breast cancer
    • Diffuse optical tomography
    • Longitudinal analysis
    • Neoadjuvant chemotherapy
    • PCR
    • Total hemoglobin

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Atomic and Molecular Physics, and Optics
    • Biomaterials
    • Radiology Nuclear Medicine and imaging

    Fingerprint

    Dive into the research topics of 'Total hemoglobin changes in the breast tumors of patients undergoing neoadjuvant chemotherapy: A longitudinal analysis'. Together they form a unique fingerprint.

    Cite this