@inproceedings{37b86c92fefa419e9704a28c65802666,
title = "Total hemoglobin changes in the breast tumors of patients undergoing neoadjuvant chemotherapy: A longitudinal analysis",
abstract = "Optical imaging techniques have emerged as a possible alternative to predict pathological complete response (pCR) in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). Our team developed a so-called diffuse optical tomographic breast imaging system (DOTBIS) which does not require the use of contrast agents or compression and enables imaging of the whole breast volume using low intensity near infrared light capable to measure tissue concentration of total hemoglobin (ctTHb). In this retrospective study, we evaluated 55 stage II-III BC patients in the neoadjuvant setting who received weekly paclitaxel x 12, followed by dose-dense adriamycin/cyclophosphamide every 2 weeks x 4. DOTBIS images were acquired from the patient whole breast volume at 6 different time points: at baseline (TP0); two weeks after the first taxane infusion (TP1); after four infusions of taxane (TP2); at the end of the taxane regimen and before starting AC cycle (TP3); after two AC infusions (TP4); and at the end of NAC and before surgery (TP5). In order to evaluate whether pCR status influences the change of ctTHb over time, we designed a multilevel mixed-effect model. pCR was defined as no invasive tumor cells from the breast and axillary tissue at surgery (ypT0 ypN0). Changes in ctTHb levels compared to baseline (TP0) values were statistically significant different between pCR (n = 20) and non-pCR (n=35) at all time points except at TP1 and at the end of the taxane cycle (TP3).",
keywords = "Breast cancer, Diffuse optical tomography, Longitudinal analysis, Neoadjuvant chemotherapy, PCR, Total hemoglobin",
author = "Altoe, {Mirella L.} and Alessandro Marone and Kim, {Hyun K.} and Hua Guo and Haninna Hibshoosh and Mariella Tejada and Crew, {Katherine D.} and Accordino, {Melissa K.} and Trivedi, {Meghna S.} and Kevin Kalinsky and Hershman, {Dawn L.} and Hielscher, {Andreas H.}",
note = "Funding Information: This work was supported in part by a grant from the Columbia Biomedical Engineering Technology Accelerator (BiomedX) and the Breast Cancer Research Foundation. Kevin Kalinsky was supported in part by the Irving Scholar Award. Furthermore, Mirella L. Alto{\'e}was supported in part by a fellowship from CNPq/LASPAU – Brazil [207913/2014-5], and Alessandro Marone was supported in part by a Personalized Medicine Fellowship of the Irving Institute for Clinical and Translational Research at Columbia University in the City of New York. Funding Information: This work was supported in part by a grant from the Columbia Biomedical Engineering Technology Accelerator (BiomedX) and the Breast Cancer Research Foundation. Kevin Kalinsky was supported in part by the Irving Scholar Award. Furthermore, Mirella L. Alto? was supported in part by a fellowship from CNPq/LASPAU ? Brazil [207913/2014-5], and Alessandro Marone was supported in part by a Personalized Medicine Fellowship of the Irving Institute for Clinical and Translational Research at Columbia University in the City of New York. Publisher Copyright: {\textcopyright} 2021 SPIE; Optical Tomography and Spectroscopy of Tissue XIV 2021 ; Conference date: 06-03-2021 Through 11-03-2021",
year = "2021",
doi = "10.1117/12.2583101",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Sergio Fantini and Paola Taroni",
booktitle = "Optical Tomography and Spectroscopy of Tissue XIV",
}