Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2

Bichu Cheng, Rolf Müller, Dirk Trauner

Research output: Contribution to journalArticlepeer-review

Abstract

The cystobactamids are a family of antibacterial natural products with unprecedented chemical scaffolds that are active against both Gram-positive and Gram-negative pathogens. Herein, we describe the first total synthesis of cystobactamid 919-2 from three fragments. Our convergent synthesis enabled both the confirmation of the correct structure and the determination of the absolute configuration of cystobactamid 919-2.

Original languageEnglish (US)
Pages (from-to)12755-12759
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number41
DOIs
StatePublished - 2017

Keywords

  • absolute configuration
  • antibiotics
  • peptides
  • structure elucidation
  • total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2'. Together they form a unique fingerprint.

Cite this