@article{a9ece3274bd44e9882dfccf5f11505c5,
title = "Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2",
abstract = "The cystobactamids are a family of antibacterial natural products with unprecedented chemical scaffolds that are active against both Gram-positive and Gram-negative pathogens. Herein, we describe the first total synthesis of cystobactamid 919-2 from three fragments. Our convergent synthesis enabled both the confirmation of the correct structure and the determination of the absolute configuration of cystobactamid 919-2.",
keywords = "absolute configuration, antibiotics, peptides, structure elucidation, total synthesis",
author = "Bichu Cheng and Rolf M{\"u}ller and Dirk Trauner",
note = "Funding Information: This work was supported by the European Science Foundation (ERC Advanced Grant 268795 to D.T.) and the Deutsche Forschungsgemeinschaft (SFB 749). We thank Dr. Peter Mayer for the X-ray crystal-structure analysis, Dr. Chin Lin for assistance with 1H–15N HMBC measurements, Dr. Ste-phan H{\"u}ttel for a natural sample of cystobactamid 919-2, Dr. Kirsten Harmrolfs for the NMR mixing experiments, Alexander Popoff for the optical rotation and CD spectra of the natural and mixed samples, Dr. Viktoria Schmitt for the bioassay, and Dr. Frits Kamp and Brigitte Nuscher for assistance in the measurement of circular dichroism spectra. We also thank Ben Williams for helpful discussions during the preparation of this manuscript. Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2017",
month = oct,
day = "2",
doi = "10.1002/anie.201705387",
language = "English (US)",
volume = "56",
pages = "12755--12759",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "41",
}