Total synthesis of (-)-archazolid B

Paul A. Roethle, Ingrid T. Chen, Dirk Trauner

Research output: Contribution to journalArticle


A highly convergent synthesis of archazolid B, a potent and highly selective V-ATPase inhibitor, is described. A relay ring-closing metathesis reaction was used to form the 24-membered macrocyclic lactone, whereas the sensitive cis-triene moiety of the archazolids was assembled with a modified Stille coupling.

Original languageEnglish (US)
Pages (from-to)8960-8961
Number of pages2
JournalJournal of the American Chemical Society
Issue number29
StatePublished - Jul 25 2007

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Total synthesis of (-)-archazolid B'. Together they form a unique fingerprint.

  • Cite this

    Roethle, P. A., Chen, I. T., & Trauner, D. (2007). Total synthesis of (-)-archazolid B. Journal of the American Chemical Society, 129(29), 8960-8961.