Total synthesis of (-)-archazolid B

Paul A. Roethle; Ingrid T. Chen; Dirk Trauner

doi:10.1021/ja0733033

Total synthesis of (-)-archazolid B

Paul A. Roethle, Ingrid T. Chen, Dirk Trauner

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A highly convergent synthesis of archazolid B, a potent and highly selective V-ATPase inhibitor, is described. A relay ring-closing metathesis reaction was used to form the 24-membered macrocyclic lactone, whereas the sensitive cis-triene moiety of the archazolids was assembled with a modified Stille coupling.

Original language	English (US)
Pages (from-to)	8960-8961
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	29
DOIs	https://doi.org/10.1021/ja0733033
State	Published - Jul 25 2007

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja0733033

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title = "Total synthesis of (-)-archazolid B",

abstract = "A highly convergent synthesis of archazolid B, a potent and highly selective V-ATPase inhibitor, is described. A relay ring-closing metathesis reaction was used to form the 24-membered macrocyclic lactone, whereas the sensitive cis-triene moiety of the archazolids was assembled with a modified Stille coupling.",

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AU - Trauner, Dirk

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AB - A highly convergent synthesis of archazolid B, a potent and highly selective V-ATPase inhibitor, is described. A relay ring-closing metathesis reaction was used to form the 24-membered macrocyclic lactone, whereas the sensitive cis-triene moiety of the archazolids was assembled with a modified Stille coupling.

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Total synthesis of (-)-archazolid B

Abstract

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