Total synthesis of (-)-archazolid B

Paul A. Roethle, Ingrid T. Chen, Dirk Trauner

Research output: Contribution to journalArticlepeer-review

Abstract

A highly convergent synthesis of archazolid B, a potent and highly selective V-ATPase inhibitor, is described. A relay ring-closing metathesis reaction was used to form the 24-membered macrocyclic lactone, whereas the sensitive cis-triene moiety of the archazolids was assembled with a modified Stille coupling.

Original languageEnglish (US)
Pages (from-to)8960-8961
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number29
DOIs
StatePublished - Jul 25 2007

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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