Total Synthesis of (±)-Exotine B

Bichu Cheng; Giulio Volpin; Johannes Morstein; Dirk Trauner

doi:10.1021/acs.orglett.8b01817

Total Synthesis of (±)-Exotine B

Bichu Cheng, Giulio Volpin, Johannes Morstein, Dirk Trauner

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The heterodimeric indole/coumarin natural product exotine B was synthesized for the first time. The carbon skeleton of the natural product was formed rapidly by a palladium-catalyzed Suzuki cross-coupling reaction and a gallium-catalyzed three-component [4 + 3] cycloaddition reaction. An alternative biosynthesis of exotine B is proposed based on the total synthesis. Improved syntheses of coumarin natural products gleinadiene and coumurrayin are also reported.

Original language	English (US)
Pages (from-to)	4358-4361
Number of pages	4
Journal	Organic Letters
Volume	20
Issue number	14
DOIs	https://doi.org/10.1021/acs.orglett.8b01817
State	Published - Jul 20 2018

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/acs.orglett.8b01817

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author = "Bichu Cheng and Giulio Volpin and Johannes Morstein and Dirk Trauner",

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AU - Trauner, Dirk

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Total Synthesis of (±)-Exotine B

Abstract

ASJC Scopus subject areas

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