Abstract
The heterodimeric indole/coumarin natural product exotine B was synthesized for the first time. The carbon skeleton of the natural product was formed rapidly by a palladium-catalyzed Suzuki cross-coupling reaction and a gallium-catalyzed three-component [4 + 3] cycloaddition reaction. An alternative biosynthesis of exotine B is proposed based on the total synthesis. Improved syntheses of coumarin natural products gleinadiene and coumurrayin are also reported.
Original language | English (US) |
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Pages (from-to) | 4358-4361 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 20 |
Issue number | 14 |
DOIs | |
State | Published - Jul 20 2018 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry