Total synthesis of (±)-rhazinal using novel palladium-catalyzed cyclizations

Alfred L. Bowie; Dirk Trauner

doi:10.1021/jo801791j

Total synthesis of (±)-rhazinal using novel palladium-catalyzed cyclizations

Alfred L. Bowie, Dirk Trauner

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A concise synthesis of (±)-rhazinal that hinges on novel oxidative Heck cyclizations and palladium- catalyzed direct couplings is described. An X-ray structure of N-MOM-rhazinal, which provides insight into the conformation of the strained 9-membered lactam ring, is described.

Original language	English (US)
Pages (from-to)	1581-1586
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	74
Issue number	4
DOIs	https://doi.org/10.1021/jo801791j
State	Published - Feb 20 2009

ASJC Scopus subject areas

Organic Chemistry

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title = "Total synthesis of (±)-rhazinal using novel palladium-catalyzed cyclizations",

abstract = "A concise synthesis of (±)-rhazinal that hinges on novel oxidative Heck cyclizations and palladium- catalyzed direct couplings is described. An X-ray structure of N-MOM-rhazinal, which provides insight into the conformation of the strained 9-membered lactam ring, is described.",

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AB - A concise synthesis of (±)-rhazinal that hinges on novel oxidative Heck cyclizations and palladium- catalyzed direct couplings is described. An X-ray structure of N-MOM-rhazinal, which provides insight into the conformation of the strained 9-membered lactam ring, is described.

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Total synthesis of (±)-rhazinal using novel palladium-catalyzed cyclizations

Abstract

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