Total synthesis of (-)-SNF4435 C and (+)-SNF4435 D

Christopher M. Beaudry, Dirk Trauner

Research output: Contribution to journalArticlepeer-review


(Chemical Equation Presented) A convergent, biomimetic total synthesis of the immunosuppressant polyketides SNF4435 C and D is described. The synthetic pathway features a stereo- and regioselective [3,3]-sigmatropic rearrangement as well as a high-yielding Stille coupling/8π-6π electrocyclization cascade.

Original languageEnglish (US)
Pages (from-to)4475-4477
Number of pages3
JournalOrganic Letters
Issue number20
StatePublished - Sep 29 2005

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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