(Chemical Equation Presented) A convergent, biomimetic total synthesis of the immunosuppressant polyketides SNF4435 C and D is described. The synthetic pathway features a stereo- and regioselective [3,3]-sigmatropic rearrangement as well as a high-yielding Stille coupling/8π-6π electrocyclization cascade.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry