TY - JOUR
T1 - Toward 20 T magnetic resonance for human brain studies
T2 - opportunities for discovery and neuroscience rationale
AU - Budinger, Thomas F.
AU - Bird, Mark D.
AU - Frydman, Lucio
AU - Long, Joanna R.
AU - Mareci, Thomas H.
AU - Rooney, William D.
AU - Rosen, Bruce
AU - Schenck, John F.
AU - Schepkin, Victor D.
AU - Sherry, A. Dean
AU - Sodickson, Daniel K.
AU - Springer, Charles S.
AU - Thulborn, Keith R.
AU - Uğurbil, Kamil
AU - Wald, Lawrence L.
N1 - Publisher Copyright:
© 2016, ESMRMB.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - An initiative to design and build magnetic resonance imaging (MRI) and spectroscopy (MRS) instruments at 14 T and beyond to 20 T has been underway since 2012. This initiative has been supported by 22 interested participants from the USA and Europe, of which 15 are authors of this review. Advances in high temperature superconductor materials, advances in cryocooling engineering, prospects for non-persistent mode stable magnets, and experiences gained from large-bore, high-field magnet engineering for the nuclear fusion endeavors support the feasibility of a human brain MRI and MRS system with 1 ppm homogeneity over at least a 16-cm diameter volume and a bore size of 68 cm. Twelve neuroscience opportunities are presented as well as an analysis of the biophysical and physiological effects to be investigated before exposing human subjects to the high fields of 14 T and beyond.
AB - An initiative to design and build magnetic resonance imaging (MRI) and spectroscopy (MRS) instruments at 14 T and beyond to 20 T has been underway since 2012. This initiative has been supported by 22 interested participants from the USA and Europe, of which 15 are authors of this review. Advances in high temperature superconductor materials, advances in cryocooling engineering, prospects for non-persistent mode stable magnets, and experiences gained from large-bore, high-field magnet engineering for the nuclear fusion endeavors support the feasibility of a human brain MRI and MRS system with 1 ppm homogeneity over at least a 16-cm diameter volume and a bore size of 68 cm. Twelve neuroscience opportunities are presented as well as an analysis of the biophysical and physiological effects to be investigated before exposing human subjects to the high fields of 14 T and beyond.
KW - Diffusion tensor imaging
KW - High temperature superconductors
KW - Human brain chemistry
KW - Magnetic field physiologic effects
KW - Magnetic resonance imaging
KW - Parallel transmit and receive strategies
KW - Ultrahigh magnetic fields
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U2 - 10.1007/s10334-016-0561-4
DO - 10.1007/s10334-016-0561-4
M3 - Review article
C2 - 27194154
AN - SCOPUS:84969792566
SN - 0968-5243
VL - 29
SP - 617
EP - 639
JO - Magnetic Resonance Materials in Physics, Biology and Medicine
JF - Magnetic Resonance Materials in Physics, Biology and Medicine
IS - 3
ER -