Toward convergence of experimental studies and theoretical modeling of the chromatin fiber

Tamar Schlick, Jeff Hayes, Sergei Grigoryev

Research output: Contribution to journalShort survey

Abstract

Understanding the structural organization of eukaryotic chromatin and its control of gene expression represents one of the most fundamental and open challenges in modern biology. Recent experimental advances have revealed important characteristics of chromatin in response to changes in external conditions and histone composition, such as the conformational complexity of linker DNA and histone tail domains upon compact folding of the fiber. In addition, modeling studies based on high-resolution nucleosome models have helped explain the conformational features of chromatin structural elements and their interactions in terms of chromatin fiber models. This minireview discusses recent progress and evidence supporting structural heterogeneity in chromatin fibers, reconciling apparently contradictory fiber models.

Original languageEnglish (US)
Pages (from-to)5183-5191
Number of pages9
JournalJournal of Biological Chemistry
Volume287
Issue number8
DOIs
StatePublished - Feb 17 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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