Toward the total synthesis of divergolides C and D

Anastasia Hager; Christian A. Kuttruff; Dominik Hager; Daniel W. Terwilliger; Dirk Trauner

doi:10.1055/s-0033-1338974

Toward the total synthesis of divergolides C and D

Anastasia Hager, Christian A. Kuttruff, Dominik Hager, Daniel W. Terwilliger, Dirk Trauner

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The divergolides are a family of structurally unprecedented ansa macrocycles. We describe a synthetic strategy toward divergolides C and D that hinges on the biomimetic diversification of a common intermediate. An advanced precursor that incorporates all the carbon atoms of divergolide C and D is presented, and atropisomerism in a sterically crowded acyl naphthalene is studied.

Original language	English (US)
Article number	ST-2013-B0557-L
Pages (from-to)	1915-1920
Number of pages	6
Journal	Synlett
Volume	24
Issue number	15
DOIs	https://doi.org/10.1055/s-0033-1338974
State	Published - 2013

Keywords

ansamycins
atropisomerism
divergent synthesis
macrolides
natural products

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-0033-1338974

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AU - Hager, Dominik

AU - Terwilliger, Daniel W.

AU - Trauner, Dirk

PY - 2013

Y1 - 2013

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AB - The divergolides are a family of structurally unprecedented ansa macrocycles. We describe a synthetic strategy toward divergolides C and D that hinges on the biomimetic diversification of a common intermediate. An advanced precursor that incorporates all the carbon atoms of divergolide C and D is presented, and atropisomerism in a sterically crowded acyl naphthalene is studied.

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KW - macrolides

KW - natural products

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Toward the total synthesis of divergolides C and D

Abstract

Keywords

ASJC Scopus subject areas

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