Toward the total synthesis of divergolides C and D

Anastasia Hager, Christian A. Kuttruff, Dominik Hager, Daniel W. Terwilliger, Dirk Trauner

Research output: Contribution to journalArticlepeer-review

Abstract

The divergolides are a family of structurally unprecedented ansa macrocycles. We describe a synthetic strategy toward divergolides C and D that hinges on the biomimetic diversification of a common intermediate. An advanced precursor that incorporates all the carbon atoms of divergolide C and D is presented, and atropisomerism in a sterically crowded acyl naphthalene is studied.

Original languageEnglish (US)
Article numberST-2013-B0557-L
Pages (from-to)1915-1920
Number of pages6
JournalSynlett
Volume24
Issue number15
DOIs
StatePublished - 2013

Keywords

  • ansamycins
  • atropisomerism
  • divergent synthesis
  • macrolides
  • natural products

ASJC Scopus subject areas

  • Organic Chemistry

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