Toward theranostic nanoparticles: CB[7] -functionalized iron oxide for drug delivery and MRI

Farah Benyettou, Irena Milosevic, Yoann Lalatonne, Fabienne Warmont, Rana Assah, John Carl Olsen, Mustapha Jouaid, Laurence Motte, Carlos Platas-Iglesias, Ali Trabolsi

Research output: Contribution to journalArticle

Abstract

Iron oxide (γ-Fe2O3) nanoparticles (NPs) were efficiently coated with the water soluble macrocycle cucurbit[7]uril (CB[7]) by microwave heating. Density functional theory (DFT) calculations support a binding model in which the carbonyl oxygens of CB[7] coordinate directly to surface Fe3+ ions. The modified particles (CB[7]NPs) are stable under a wide pH range (2-12) and have a transverse relaxivity, R2, of 113 s-1 mM-1. Nile red (NR) dye was loaded into the cavities of the surface-adsorbed CB[7]s, and intracellular delivery of the dye to HCT116 cells was observed by confocal laser scanning microscopy. The dye-loaded particles (CB[7]NPs⊃NR) have a R2 of 172 s-1 mM -1. The stability, biocompatibility, and dual purpose functionality (drug delivery and magnetic resonance imaging) of the CB[7]NPs herald the theranostic potential of this system.

Original languageEnglish (US)
Pages (from-to)5076-5082
Number of pages7
JournalJournal of Materials Chemistry B
Volume1
Issue number38
DOIs
StatePublished - Oct 14 2013

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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    Benyettou, F., Milosevic, I., Lalatonne, Y., Warmont, F., Assah, R., Olsen, J. C., Jouaid, M., Motte, L., Platas-Iglesias, C., & Trabolsi, A. (2013). Toward theranostic nanoparticles: CB[7] -functionalized iron oxide for drug delivery and MRI. Journal of Materials Chemistry B, 1(38), 5076-5082. https://doi.org/10.1039/c3tb20852d