TY - JOUR
T1 - Toward theranostic nanoparticles
T2 - CB[7] -functionalized iron oxide for drug delivery and MRI
AU - Benyettou, Farah
AU - Milosevic, Irena
AU - Lalatonne, Yoann
AU - Warmont, Fabienne
AU - Assah, Rana
AU - Olsen, John Carl
AU - Jouaid, Mustapha
AU - Motte, Laurence
AU - Platas-Iglesias, Carlos
AU - Trabolsi, Ali
PY - 2013/10/14
Y1 - 2013/10/14
N2 - Iron oxide (γ-Fe2O3) nanoparticles (NPs) were efficiently coated with the water soluble macrocycle cucurbit[7]uril (CB[7]) by microwave heating. Density functional theory (DFT) calculations support a binding model in which the carbonyl oxygens of CB[7] coordinate directly to surface Fe3+ ions. The modified particles (CB[7]NPs) are stable under a wide pH range (2-12) and have a transverse relaxivity, R2, of 113 s-1 mM-1. Nile red (NR) dye was loaded into the cavities of the surface-adsorbed CB[7]s, and intracellular delivery of the dye to HCT116 cells was observed by confocal laser scanning microscopy. The dye-loaded particles (CB[7]NPs⊃NR) have a R2 of 172 s-1 mM -1. The stability, biocompatibility, and dual purpose functionality (drug delivery and magnetic resonance imaging) of the CB[7]NPs herald the theranostic potential of this system.
AB - Iron oxide (γ-Fe2O3) nanoparticles (NPs) were efficiently coated with the water soluble macrocycle cucurbit[7]uril (CB[7]) by microwave heating. Density functional theory (DFT) calculations support a binding model in which the carbonyl oxygens of CB[7] coordinate directly to surface Fe3+ ions. The modified particles (CB[7]NPs) are stable under a wide pH range (2-12) and have a transverse relaxivity, R2, of 113 s-1 mM-1. Nile red (NR) dye was loaded into the cavities of the surface-adsorbed CB[7]s, and intracellular delivery of the dye to HCT116 cells was observed by confocal laser scanning microscopy. The dye-loaded particles (CB[7]NPs⊃NR) have a R2 of 172 s-1 mM -1. The stability, biocompatibility, and dual purpose functionality (drug delivery and magnetic resonance imaging) of the CB[7]NPs herald the theranostic potential of this system.
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U2 - 10.1039/c3tb20852d
DO - 10.1039/c3tb20852d
M3 - Article
AN - SCOPUS:84883884449
SN - 2050-7518
VL - 1
SP - 5076
EP - 5082
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 38
ER -