Towards self-replicating materials of DNA functionalized colloidal particles

Mirjam E. Leunissen; Remi Dreyfus; Roujie Sha; Tong Wang; Nadrian C. Seeman; David J. Pine; Paul M. Chaikin

Towards self-replicating materials of DNA functionalized colloidal particles

Mirjam E. Leunissen, Remi Dreyfus, Roujie Sha, Tong Wang, Nadrian C. Seeman, David J. Pine, Paul M. Chaikin

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Our aim is the construction of a new class of non-biological materials that can self-replicate and, as a result, grow exponentially. We propose a strategy that exploits the specificity and thermal reversibility of the interactions between colloidal particles functionalized with complementary single-stranded DNA 'sticky ends'. Here, we experimentally test the fundamentals and various components of the self-replication scheme. This includes studies of the equilibrium and kinetic aspects of the DNA-mediated aggregation-dissociation behavior of the particles, of the cross-linking method to selectively make permanent bonds between the particles, of the dual recognition capability of bifunctionalized beads, and of the organization of individual particles on the 'seed' structure that lies at the basis of the self-replication scheme.

Original language	English (US)
Title of host publication	Extended Abstracts for 6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009
Pages	172-176
Number of pages	5
State	Published - 2009
Event	6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009 - Snowbird, UT, United States Duration: Apr 20 2009 → Apr 24 2009

Other

Other	6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009
Country/Territory	United States
City	Snowbird, UT
Period	4/20/09 → 4/24/09

ASJC Scopus subject areas

Hardware and Architecture
Electrical and Electronic Engineering

Cite this

Towards self-replicating materials of DNA functionalized colloidal particles. / Leunissen, Mirjam E.; Dreyfus, Remi; Sha, Roujie et al.
Extended Abstracts for 6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009. 2009. p. 172-176.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Leunissen, ME, Dreyfus, R, Sha, R, Wang, T, Seeman, NC, Pine, DJ & Chaikin, PM 2009, Towards self-replicating materials of DNA functionalized colloidal particles. in Extended Abstracts for 6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009. pp. 172-176, 6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009, Snowbird, UT, United States, 4/20/09.

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AU - Leunissen, Mirjam E.

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AU - Pine, David J.

AU - Chaikin, Paul M.

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AB - Our aim is the construction of a new class of non-biological materials that can self-replicate and, as a result, grow exponentially. We propose a strategy that exploits the specificity and thermal reversibility of the interactions between colloidal particles functionalized with complementary single-stranded DNA 'sticky ends'. Here, we experimentally test the fundamentals and various components of the self-replication scheme. This includes studies of the equilibrium and kinetic aspects of the DNA-mediated aggregation-dissociation behavior of the particles, of the cross-linking method to selectively make permanent bonds between the particles, of the dual recognition capability of bifunctionalized beads, and of the organization of individual particles on the 'seed' structure that lies at the basis of the self-replication scheme.

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Towards self-replicating materials of DNA functionalized colloidal particles

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ASJC Scopus subject areas

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