Towards self-replicating materials of DNA functionalized colloidal particles

Mirjam E. Leunissen, Remi Dreyfus, Roujie Sha, Tong Wang, Nadrian C. Seeman, David J. Pine, Paul M. Chaikin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Our aim is the construction of a new class of non-biological materials that can self-replicate and, as a result, grow exponentially. We propose a strategy that exploits the specificity and thermal reversibility of the interactions between colloidal particles functionalized with complementary single-stranded DNA 'sticky ends'. Here, we experimentally test the fundamentals and various components of the self-replication scheme. This includes studies of the equilibrium and kinetic aspects of the DNA-mediated aggregation-dissociation behavior of the particles, of the cross-linking method to selectively make permanent bonds between the particles, of the dual recognition capability of bifunctionalized beads, and of the organization of individual particles on the 'seed' structure that lies at the basis of the self-replication scheme.

Original languageEnglish (US)
Title of host publicationExtended Abstracts for 6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009
Pages172-176
Number of pages5
StatePublished - 2009
Event6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009 - Snowbird, UT, United States
Duration: Apr 20 2009Apr 24 2009

Other

Other6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009
CountryUnited States
CitySnowbird, UT
Period4/20/094/24/09

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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    Leunissen, M. E., Dreyfus, R., Sha, R., Wang, T., Seeman, N. C., Pine, D. J., & Chaikin, P. M. (2009). Towards self-replicating materials of DNA functionalized colloidal particles. In Extended Abstracts for 6th Annual Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2009 (pp. 172-176)