Toxicity of graphene in normal human lung cells (BEAS-2B)

N. V.Srikanth Vallabani; Sandeep Mittal; Ritesh K. Shukla; Alok K. Pandey; Sanjay R. Dhakate; Renu Pasricha; Alok Dhawan

doi:10.1166/jbn.2011.1224

Toxicity of graphene in normal human lung cells (BEAS-2B)

N. V.Srikanth Vallabani, Sandeep Mittal, Ritesh K. Shukla, Alok K. Pandey, Sanjay R. Dhakate, Renu Pasricha, Alok Dhawan

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Abstract

Graphite nanomaterials such as thermally exfoliated graphite oxide (GO) are versatile in many applications. However, little is known about its effects on biological systems. In this study we characrerized the GO using dynamic light scattering (DLS) along with the toxicological aspects related to cytotoxicity and apoptosis in normal human lung cells (BEAS-2B). A significant concentration and time dependent decrease in cell viability was observed at different concentrations (10-100 μg/ml) by the MTT assay after 24 and 48 h of exposure and significant increase of early and late apoptotic cells was observed as compared to control cells. Our study demonstrates that GO induces cytotoxicity and apoptosis in human lung cells.

Original language	English (US)
Pages (from-to)	106-107
Number of pages	2
Journal	Journal of Biomedical Nanotechnology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1166/jbn.2011.1224
State	Published - Jan 2011

Keywords

Graphene
Human lung cells
Thermally exfoliated graphite oxide

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science
Pharmaceutical Science

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10.1166/jbn.2011.1224

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abstract = "Graphite nanomaterials such as thermally exfoliated graphite oxide (GO) are versatile in many applications. However, little is known about its effects on biological systems. In this study we characrerized the GO using dynamic light scattering (DLS) along with the toxicological aspects related to cytotoxicity and apoptosis in normal human lung cells (BEAS-2B). A significant concentration and time dependent decrease in cell viability was observed at different concentrations (10-100 μg/ml) by the MTT assay after 24 and 48 h of exposure and significant increase of early and late apoptotic cells was observed as compared to control cells. Our study demonstrates that GO induces cytotoxicity and apoptosis in human lung cells.",

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AU - Vallabani, N. V.Srikanth

AU - Mittal, Sandeep

AU - Shukla, Ritesh K.

AU - Pandey, Alok K.

AU - Dhakate, Sanjay R.

AU - Pasricha, Renu

AU - Dhawan, Alok

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Toxicity of graphene in normal human lung cells (BEAS-2B)

Abstract

Keywords

ASJC Scopus subject areas

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