Tracking the fear engram: The lateral amygdala is an essential locus of fear memory storage

Glenn E. Schafe, Valérie Doyère, Joseph E. LeDoux

Research output: Contribution to journalArticle

Abstract

Although it is believed that different types of memories are localized in discreet regions of the brain, concrete experimental evidence of the existence of such engrams is often elusive. Despite being one of the best characterized memory systems of the brain, the question of where fear memories are localized in the brain remains a hotly debated issue. Here, we combine site-specific behavioral pharmacology with multisite electrophysiological recording techniques to show that the lateral nucleus of the amygdala, long thought to be critical for the acquisition of fear memories, is also an essential locus of fear memory storage.

Original languageEnglish (US)
Pages (from-to)10010-10015
Number of pages6
JournalJournal of Neuroscience
Volume25
Issue number43
DOIs
StatePublished - Oct 26 2005

Keywords

  • Amygdala
  • Fear conditioning
  • MAP kinase
  • Memory consolidation
  • Rat
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

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