TY - JOUR
T1 - Tracting the neural basis of music
T2 - Deficient structural connectivity underlying acquired amusia
AU - Sihvonen, Aleksi J.
AU - Ripollés, Pablo
AU - Särkämö, Teppo
AU - Leo, Vera
AU - Rodríguez-Fornells, Antoni
AU - Saunavaara, Jani
AU - Parkkola, Riitta
AU - Soinila, Seppo
N1 - Funding Information:
This work was supported by Academy of Finland program (grants no. 1257077, 1277693), Tyks Research Funding (grant no. 13944), Finnish Brain Research and Rehabilitation Foundation, Finnish Brain Foundation, Ella and Georg Ehrnrooth Foundation, Signe and Ane Gyllenberg Foundation, Maire Taponen Foundation, Finnish Cultural Foundation, National Doctoral Programme of Psychology, Jenny and Antti Wihuri Foundation, the Formaci?n de Profesorado Universitario program (AP2010-4170) and Generalitat de Catalunya (2014 SGR1413).
Funding Information:
This work was supported by Academy of Finland program (grants no. 1257077 , 1277693 ), Tyks Research Funding (grant no. 13944 ), Finnish Brain Research and Rehabilitation Foundation , Finnish Brain Foundation , Ella and Georg Ehrnrooth Foundation , Signe and Ane Gyllenberg Foundation , Maire Taponen Foundation , Finnish Cultural Foundation , National Doctoral Programme of Psychology, Jenny and Antti Wihuri Foundation , the Formación de Profesorado Universitario program ( AP2010-4170 ) and Generalitat de Catalunya (2014 SGR1413 ).
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/12
Y1 - 2017/12
N2 - Acquired amusia provides a unique opportunity to investigate the fundamental neural architectures of musical processing due to the transition from a functioning to defective music processing system. Yet, the white matter (WM) deficits in amusia remain systematically unexplored. To evaluate which WM structures form the neural basis for acquired amusia and its recovery, we studied 42 stroke patients longitudinally at acute, 3-month, and 6-month post-stroke stages using DTI [tract-based spatial statistics (TBSS) and deterministic tractography (DT)] and the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA). Non-recovered amusia was associated with structural damage and subsequent degeneration in multiple WM tracts including the right inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF), and frontal aslant tract (FAT), as well as in the corpus callosum (CC) and its posterior part (tapetum). In a linear regression analysis, the volume of the right IFOF was the main predictor of MBEA performance across time. Overall, our results provide a comprehensive picture of the large-scale deficits in intra- and interhemispheric structural connectivity underlying amusia, and conversely highlight which pathways are crucial for normal music perception.
AB - Acquired amusia provides a unique opportunity to investigate the fundamental neural architectures of musical processing due to the transition from a functioning to defective music processing system. Yet, the white matter (WM) deficits in amusia remain systematically unexplored. To evaluate which WM structures form the neural basis for acquired amusia and its recovery, we studied 42 stroke patients longitudinally at acute, 3-month, and 6-month post-stroke stages using DTI [tract-based spatial statistics (TBSS) and deterministic tractography (DT)] and the Scale and Rhythm subtests of the Montreal Battery of Evaluation of Amusia (MBEA). Non-recovered amusia was associated with structural damage and subsequent degeneration in multiple WM tracts including the right inferior fronto-occipital fasciculus (IFOF), arcuate fasciculus (AF), inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF), and frontal aslant tract (FAT), as well as in the corpus callosum (CC) and its posterior part (tapetum). In a linear regression analysis, the volume of the right IFOF was the main predictor of MBEA performance across time. Overall, our results provide a comprehensive picture of the large-scale deficits in intra- and interhemispheric structural connectivity underlying amusia, and conversely highlight which pathways are crucial for normal music perception.
KW - Amusia
KW - Music
KW - Stroke
KW - Tract-based spatial statistics
KW - Tractography
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U2 - 10.1016/j.cortex.2017.09.028
DO - 10.1016/j.cortex.2017.09.028
M3 - Article
C2 - 29100660
AN - SCOPUS:85032973284
VL - 97
SP - 255
EP - 273
JO - Cortex
JF - Cortex
SN - 0010-9452
ER -