@article{00495f9e94c24146ac2fc0f6efb4f73d,
title = "Trajectories of cognitive function and associated phenotypic and genotypic factors in breast cancer",
abstract = "OBJECTIVES: This study identified women with unique trajectories of executive function, concentration, and visual working memory before and during adjuvant therapy for breast cancer, and examined phenotypic and genotypic predictors associated with subgroups. SAMPLE & SETTING: 399 postmenopausal women, of whom 288 were women with early-stage breast cancer and 111 were women without breast cancer, matched on age and years of education to the women with breast cancer, and all at an urban cancer center. METHODS & VARIABLES: A repeated-measures design was used; assessments occurred before adjuvant therapy and every six months post-therapy initiation. Group-based trajectory modeling determined subgroups. Multinomial logistic regression identified phenotypic and genotypic characteristics. RESULTS: Three executive function and concentration trajectory subgroups were identified: low, moderate, and high; two visual working memory subgroups were identified: low and high. IMPLICATIONS FOR NURSING: Advancing age, greater pretherapy fatigue, and poorer pretherapy cognitive function are associated with the low subgroups. DNA repair and oxidative stress mechanisms may be involved in the cognitive changes that women experience.",
keywords = "Aromatase inhibitor, Breast cancer, Cognitive function, Genotypic, Phenotypic",
author = "Bender, {Catherine M.} and Merriman, {John D.} and Sereika, {Susan M.} and Gentry, {Amanda L.} and Casillo, {Frances E.} and Koleck, {Theresa A.} and Rosenzweig, {Margaret Q.} and Brufsky, {Adam M.} and Priscilla McAuliffe and Yehui Zhu and Conley, {Yvette P.}",
note = "Funding Information: Glunt Hoffman Endowed Chair in Oncology Nursing, John D. Merriman, PhD, RN, AOCNS{\textregistered}, is a postdoctoral associate, Susan M. Sereika, PhD, is a professor and director of the Center for Research and Evaluation, Amanda L. Gentry, MPH, is a project director, and Frances E. Casillo, RN, BSN, is a research associate and RN, all in the School of Nursing at the University of Pittsburgh in Pennsylvania; Theresa A. Koleck, PhD, BSN, RN, is a postdoctoral research fellow in the School of Nursing at Columbia University in New York, NY; Margaret Q. Rosenzweig, PhD, FNP-C, AOCNP{\textregistered}, FAAN, is a professor in the School of Nursing at the University of Pittsburgh; Adam M. Brufsky, MD, PhD, is a professor of medicine and associate chief of the Division of Hematology/Oncology in the Department of Medicine at the University of Pittsburgh, and codirector of the Comprehensive Breast Cancer Center and associate director of clinical investigation for the University of Pittsburgh Medical Center (UPMC) Cancer Center; Priscilla McAuliffe, MD, PhD, is an assistant professor in the Department of Surgery, Division of Surgical Oncology, at the University of Pittsburgh and UPMC Cancer Center; and Yehui Zhu, MSN, BSN, is a doctoral student and Yvette P. Conley, PhD, FAAN, is a professor, both in the School of Nursing at the University of Pittsburgh. Bender can be reached at cbe100@pitt.edu, with copy to ONFEditor@ons.org. (Submitted April 2017. Accepted November 2, 2017.) This research was funded by a grant from the National Cancer Institute (R01CA107408, principal investigator: Bender) and an award from the Oncology Nursing Society Foundation (Conley and Bender, co-principal investigators). Merriman was supported by grants from National Institute of Nursing Research (NINR) (K99NR015473 and T32NR009759), and Koleck was also supported by grants from the NINR (F31NR014590 and T32NR009759). Bender was the recipient of the 2017 ONS Congress Distinguished Nurse Researcher Award and presented a lecture at the 42nd annual ONS Congress in Denver, CO. Publisher Copyright: {\textcopyright} 2008 Oncology Nursing Society. All rights reserved.",
year = "2018",
month = may,
doi = "10.1188/18.ONF.308-326",
language = "English (US)",
volume = "45",
pages = "308--326",
journal = "Oncology Nursing Forum",
issn = "0190-535X",
publisher = "Oncology Nursing Society",
number = "3",
}