Trajectories of fear of recurrence in women with breast cancer

Laura B. Dunn, Dale J. Langford, Steven M. Paul, Molly B. Berman, Dianne M. Shumay, Kord Kober, John D. Merriman, Claudia West, John M. Neuhaus, Christine Miaskowski

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Although fear of recurrence (FCR) is common among cancer survivors, it remains unclear what factors predict initial levels (e.g., prior to surgery) or changes in FCR in the post-treatment period. Among women treated for breast cancer, this study evaluated the effects of demographic, clinical, symptom, and psychosocial adjustment characteristics on the initial (preoperative) levels of FCR and trajectories of FCR over 6 months following surgery. Methods: Prior to and for 6 months following breast cancer surgery, 396 women were assessed for demographic and clinical (disease and treatment) characteristics, symptoms, psychological adjustment characteristics, and quality of life (QOL). FCR was assessed using a four-item subscale from the QOL instrument. Hierarchical linear modeling was used to examine changes in FCR scores and to identify predictors of inter-individual differences in preoperative FCR levels and trajectories over 6 months. Results: From before surgery to 6 months post-operatively, women with breast cancer showed a high degree of inter-individual variability in FCR. Preoperatively, women who lived with someone, experienced greater changes in spiritual life, had higher state anxiety, had more difficulty coping, or experienced more distress due to diagnosis or distress to family members reported higher FCR scores. Patients who reported better overall physical health and higher FCR scores at enrollment demonstrated a steeper decrease in FCR scores over time. Conclusions: These findings highlight inter-individual heterogeneity in initial levels and changes in FCR over time among women undergoing breast cancer surgery. Further work is needed to identify and provide interventions for women experiencing FCR during and after breast cancer treatment.

Original languageEnglish (US)
Pages (from-to)2033-2043
Number of pages11
JournalSupportive Care in Cancer
Volume23
Issue number7
DOIs
StatePublished - Dec 19 2015

Keywords

  • Breast cancer
  • Fear of recurrence
  • Hierarchical linear modeling
  • Oncology
  • Psychological symptoms
  • Symptom trajectories

ASJC Scopus subject areas

  • Oncology

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