Transcription past DNA adducts derived from polycyclic aromatic hydrocarbons

Research output: Contribution to journalReview articlepeer-review

Abstract

The ability of a DNA lesion to block transcription is a function of many variables: (1) the ability of the RNA polymerase active site to accommodate the damaged base; (2) the size and shape of the adduct, which includes the specific modified base; (3) the stereochemistry of the adduct; (4) the base incorporated into the growing transcript; (5) and the local DNA sequence. Each of these parameters, either alone or in combination, can influence how a particular lesion in the genome will affect transcription elongation, resulting in potential clearance of the lesion via transcription-coupled DNA repair or in the formation of truncated or full-length transcripts that might encode defective proteins.

Original languageEnglish (US)
Pages (from-to)146-154
Number of pages9
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume577
Issue number1-2 SPEC. ISS.
DOIs
StatePublished - Sep 4 2005

Keywords

  • DNA adducts
  • DNA repair
  • Transcription elongation

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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