Transcription past DNA adducts derived from polycyclic aromatic hydrocarbons

David A. Scicchitano

doi:10.1016/j.mrfmmm.2005.03.015

Transcription past DNA adducts derived from polycyclic aromatic hydrocarbons

Research output: Contribution to journal › Review article › peer-review

Abstract

The ability of a DNA lesion to block transcription is a function of many variables: (1) the ability of the RNA polymerase active site to accommodate the damaged base; (2) the size and shape of the adduct, which includes the specific modified base; (3) the stereochemistry of the adduct; (4) the base incorporated into the growing transcript; (5) and the local DNA sequence. Each of these parameters, either alone or in combination, can influence how a particular lesion in the genome will affect transcription elongation, resulting in potential clearance of the lesion via transcription-coupled DNA repair or in the formation of truncated or full-length transcripts that might encode defective proteins.

Original language	English (US)
Pages (from-to)	146-154
Number of pages	9
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	577
Issue number	1-2 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.mrfmmm.2005.03.015
State	Published - Sep 4 2005

Keywords

DNA adducts
DNA repair
Transcription elongation

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

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10.1016/j.mrfmmm.2005.03.015

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title = "Transcription past DNA adducts derived from polycyclic aromatic hydrocarbons",

abstract = "The ability of a DNA lesion to block transcription is a function of many variables: (1) the ability of the RNA polymerase active site to accommodate the damaged base; (2) the size and shape of the adduct, which includes the specific modified base; (3) the stereochemistry of the adduct; (4) the base incorporated into the growing transcript; (5) and the local DNA sequence. Each of these parameters, either alone or in combination, can influence how a particular lesion in the genome will affect transcription elongation, resulting in potential clearance of the lesion via transcription-coupled DNA repair or in the formation of truncated or full-length transcripts that might encode defective proteins.",

keywords = "DNA adducts, DNA repair, Transcription elongation",

author = "Scicchitano, {David A.}",

note = "Funding Information: The author thanks all the members of his lab for their help with this manuscript. He also thanks Professor Nicholas Geacintov (Department of Chemistry, New York University) and Professor Suse Broyde (Department of Biology, New York University) for valuable discussion. This work was supported by NIH grant ES10581 to DAS.",

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N2 - The ability of a DNA lesion to block transcription is a function of many variables: (1) the ability of the RNA polymerase active site to accommodate the damaged base; (2) the size and shape of the adduct, which includes the specific modified base; (3) the stereochemistry of the adduct; (4) the base incorporated into the growing transcript; (5) and the local DNA sequence. Each of these parameters, either alone or in combination, can influence how a particular lesion in the genome will affect transcription elongation, resulting in potential clearance of the lesion via transcription-coupled DNA repair or in the formation of truncated or full-length transcripts that might encode defective proteins.

AB - The ability of a DNA lesion to block transcription is a function of many variables: (1) the ability of the RNA polymerase active site to accommodate the damaged base; (2) the size and shape of the adduct, which includes the specific modified base; (3) the stereochemistry of the adduct; (4) the base incorporated into the growing transcript; (5) and the local DNA sequence. Each of these parameters, either alone or in combination, can influence how a particular lesion in the genome will affect transcription elongation, resulting in potential clearance of the lesion via transcription-coupled DNA repair or in the formation of truncated or full-length transcripts that might encode defective proteins.

KW - DNA adducts

KW - DNA repair

KW - Transcription elongation

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JO - Mutation Research

JF - Mutation Research

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Transcription past DNA adducts derived from polycyclic aromatic hydrocarbons

Abstract

Keywords

ASJC Scopus subject areas

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