TY - JOUR
T1 - Transcription past DNA adducts derived from polycyclic aromatic hydrocarbons
AU - Scicchitano, David A.
N1 - Funding Information:
The author thanks all the members of his lab for their help with this manuscript. He also thanks Professor Nicholas Geacintov (Department of Chemistry, New York University) and Professor Suse Broyde (Department of Biology, New York University) for valuable discussion. This work was supported by NIH grant ES10581 to DAS.
PY - 2005/9/4
Y1 - 2005/9/4
N2 - The ability of a DNA lesion to block transcription is a function of many variables: (1) the ability of the RNA polymerase active site to accommodate the damaged base; (2) the size and shape of the adduct, which includes the specific modified base; (3) the stereochemistry of the adduct; (4) the base incorporated into the growing transcript; (5) and the local DNA sequence. Each of these parameters, either alone or in combination, can influence how a particular lesion in the genome will affect transcription elongation, resulting in potential clearance of the lesion via transcription-coupled DNA repair or in the formation of truncated or full-length transcripts that might encode defective proteins.
AB - The ability of a DNA lesion to block transcription is a function of many variables: (1) the ability of the RNA polymerase active site to accommodate the damaged base; (2) the size and shape of the adduct, which includes the specific modified base; (3) the stereochemistry of the adduct; (4) the base incorporated into the growing transcript; (5) and the local DNA sequence. Each of these parameters, either alone or in combination, can influence how a particular lesion in the genome will affect transcription elongation, resulting in potential clearance of the lesion via transcription-coupled DNA repair or in the formation of truncated or full-length transcripts that might encode defective proteins.
KW - DNA adducts
KW - DNA repair
KW - Transcription elongation
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U2 - 10.1016/j.mrfmmm.2005.03.015
DO - 10.1016/j.mrfmmm.2005.03.015
M3 - Review article
C2 - 15922365
AN - SCOPUS:24044492238
SN - 0027-5107
VL - 577
SP - 146
EP - 154
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 1-2 SPEC. ISS.
ER -