Transcriptional regulation of bone and joint remodeling by NFAT

Despina Sitara, Antonios O. Aliprantis

Research output: Contribution to journalReview article

Abstract

Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity and mortality worldwide. These diseases result from aberrant tissue remodeling leading to weak, fracture-prone bones or painful, dysfunctional joints. The nuclear factor of activated T cells (NFAT) transcription factor family controls diverse biologic processes in vertebrates. Here, we review the scientific evidence that links NFAT-regulated gene transcription to bone and joint pathology. A particular emphasis is placed on the role of NFATs in bone resorption and formation by osteoclasts and osteoblasts, respectively. In addition, emerging data that connect NFATs with cartilage biology, angiogenesis, nociception, and neurogenic inflammation are explored. The goal of this article is to highlight the importance of tissue remodeling in musculoskeletal disease and situate NFAT-driven cellular responses within this context to inspire future research endeavors.

Original languageEnglish (US)
Pages (from-to)286-300
Number of pages15
JournalImmunological Reviews
Volume233
Issue number1
DOIs
StatePublished - Jan 2010

Keywords

  • NFAT
  • Osteoarthritis
  • Osteoblast
  • Osteoclast
  • Osteoporosis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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