Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD

William E. Pelham; Lisa Burrows-MacLean; Elizabeth M. Gnagy; Gregory A. Fabiano; Erika K. Coles; Katy E. Tresco; Anil Chacko; Brian T. Wymbs; Amber L. Wienke; Kathryn S. Walker; Martin T. Hoffman

doi:10.1037/1064-1297.13.2.111

Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD

William E. Pelham, Lisa Burrows-MacLean, Elizabeth M. Gnagy, Gregory A. Fabiano, Erika K. Coles, Katy E. Tresco, Anil Chacko, Brian T. Wymbs, Amber L. Wienke, Kathryn S. Walker, Martin T. Hoffman

Research output: Contribution to journal › Article › peer-review

Abstract

Stimulant medication and behavioral treatments are evidence-based for children with attention-deficit/hyperactivity disorder, but the combination of the 2 treatments has been understudied. In this investigation, methylphenidate (MPH) was crossed with 2 levels of behavior modification (BMOD) in a summer treatment program. Twenty-seven children with attention-deficit/hyperactivity disorder, aged 6-12, participated. Children received placebo and 3 doses of transdermal MPH (12.5 cm², 25.0 cm², and 37.5 cm ²). BMOD was implemented on alternating weeks. Both treatments produced large and significant effects. Combined treatment was superior to either treatment alone. The effects of transdermal MPH were comparable to those found in this setting in previous studies with multiple stimulant medications and formulations. Consistent with other research, low doses of MPH-even lower than in previous studies-yielded enhanced effects in combination with behavior modification.

Original language	English (US)
Pages (from-to)	111-126
Number of pages	16
Journal	Experimental and Clinical Psychopharmacology
Volume	13
Issue number	2
DOIs	https://doi.org/10.1037/1064-1297.13.2.111
State	Published - May 2005

Keywords

Attention deficit hyperactivity disorder
Behavioral treatment
Combined treatment
Methylphenidate

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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10.1037/1064-1297.13.2.111

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title = "Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD",

abstract = "Stimulant medication and behavioral treatments are evidence-based for children with attention-deficit/hyperactivity disorder, but the combination of the 2 treatments has been understudied. In this investigation, methylphenidate (MPH) was crossed with 2 levels of behavior modification (BMOD) in a summer treatment program. Twenty-seven children with attention-deficit/hyperactivity disorder, aged 6-12, participated. Children received placebo and 3 doses of transdermal MPH (12.5 cm2, 25.0 cm2, and 37.5 cm 2). BMOD was implemented on alternating weeks. Both treatments produced large and significant effects. Combined treatment was superior to either treatment alone. The effects of transdermal MPH were comparable to those found in this setting in previous studies with multiple stimulant medications and formulations. Consistent with other research, low doses of MPH-even lower than in previous studies-yielded enhanced effects in combination with behavior modification.",

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AU - Coles, Erika K.

AU - Tresco, Katy E.

AU - Chacko, Anil

AU - Wymbs, Brian T.

AU - Wienke, Amber L.

AU - Walker, Kathryn S.

AU - Hoffman, Martin T.

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AB - Stimulant medication and behavioral treatments are evidence-based for children with attention-deficit/hyperactivity disorder, but the combination of the 2 treatments has been understudied. In this investigation, methylphenidate (MPH) was crossed with 2 levels of behavior modification (BMOD) in a summer treatment program. Twenty-seven children with attention-deficit/hyperactivity disorder, aged 6-12, participated. Children received placebo and 3 doses of transdermal MPH (12.5 cm2, 25.0 cm2, and 37.5 cm 2). BMOD was implemented on alternating weeks. Both treatments produced large and significant effects. Combined treatment was superior to either treatment alone. The effects of transdermal MPH were comparable to those found in this setting in previous studies with multiple stimulant medications and formulations. Consistent with other research, low doses of MPH-even lower than in previous studies-yielded enhanced effects in combination with behavior modification.

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Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD

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Keywords

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