Transition-State Stabilization and Molecular Recognition: Acceleration of Phosphoryl-Transfer Reactions by an Artificial Receptor

Paolo Tecilla; Suk Kyu Chang; Andrew D. Hamilton

doi:10.1021/ja00182a017

Transition-State Stabilization and Molecular Recognition: Acceleration of Phosphoryl-Transfer Reactions by an Artificial Receptor

Paolo Tecilla, Suk Kyu Chang, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

An artificial receptor that is complementary to the proposed trigonal-bipyramidal intermediate for phosphoryl-transfer reactions has been designed. Kinetic measurements with ³¹P NMR methods show that the receptor causes up to a 10-fold acceleration in the aminolysis of phosphorodiamidic chloride derivatives, proceeding via an associative mechanism.

Original language	English (US)
Pages (from-to)	9586-9590
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	112
Issue number	26
DOIs	https://doi.org/10.1021/ja00182a017
State	Published - Jan 1990

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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title = "Transition-State Stabilization and Molecular Recognition: Acceleration of Phosphoryl-Transfer Reactions by an Artificial Receptor",

abstract = "An artificial receptor that is complementary to the proposed trigonal-bipyramidal intermediate for phosphoryl-transfer reactions has been designed. Kinetic measurements with 31P NMR methods show that the receptor causes up to a 10-fold acceleration in the aminolysis of phosphorodiamidic chloride derivatives, proceeding via an associative mechanism.",

author = "Paolo Tecilla and Chang, {Suk Kyu} and Hamilton, {Andrew D.}",

year = "1990",

month = jan,

doi = "10.1021/ja00182a017",

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AU - Chang, Suk Kyu

AU - Hamilton, Andrew D.

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AB - An artificial receptor that is complementary to the proposed trigonal-bipyramidal intermediate for phosphoryl-transfer reactions has been designed. Kinetic measurements with 31P NMR methods show that the receptor causes up to a 10-fold acceleration in the aminolysis of phosphorodiamidic chloride derivatives, proceeding via an associative mechanism.

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Transition-State Stabilization and Molecular Recognition: Acceleration of Phosphoryl-Transfer Reactions by an Artificial Receptor

Abstract

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