Transition-State Stabilization and Molecular Recognition: Acceleration of Phosphoryl-Transfer Reactions by an Artificial Receptor

Paolo Tecilla, Suk Kyu Chang, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

An artificial receptor that is complementary to the proposed trigonal-bipyramidal intermediate for phosphoryl-transfer reactions has been designed. Kinetic measurements with 31P NMR methods show that the receptor causes up to a 10-fold acceleration in the aminolysis of phosphorodiamidic chloride derivatives, proceeding via an associative mechanism.

Original languageEnglish (US)
Pages (from-to)9586-9590
Number of pages5
JournalJournal of the American Chemical Society
Volume112
Issue number26
DOIs
StatePublished - Jan 1990

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Transition-State Stabilization and Molecular Recognition: Acceleration of Phosphoryl-Transfer Reactions by an Artificial Receptor'. Together they form a unique fingerprint.

Cite this