Translational Control Mechanisms in Synaptic Plasticity and Memory

Mauro Costa-Mattioli, Eric Klann

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The requirement of protein synthesis (translation) for long-lasting synaptic plasticity and long-term memory has been known for many years, although until recently, the mechanisms that control translation during these processes were unknown. In this chapter, recent studies that have identified translation regulatory mechanisms that govern the expression of various forms of translation-dependent synaptic plasticity and memory are discussed. Synaptic plasticity and memory deficits in genetically engineered mice that lack specific translation factors and translation regulatory proteins also are discussed. These studies have revealed interesting links among the biochemical activities of translation factors, synaptic plasticity, and memory.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd
Pages311-328
Number of pages18
ISBN (Electronic)9780128093245
DOIs
StatePublished - Jan 1 2016

Keywords

  • Associative memory
  • Fragile X mental retardation
  • Hippocampus
  • Long-term depression
  • Long-term potentiation
  • Protein synthesis
  • Spatial memory
  • Synaptic plasticity
  • Translation elongation
  • Translation initiation
  • mRNA-binding proteins

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Costa-Mattioli, M., & Klann, E. (2016). Translational Control Mechanisms in Synaptic Plasticity and Memory. In The Curated Reference Collection in Neuroscience and Biobehavioral Psychology (pp. 311-328). Elsevier Science Ltd. https://doi.org/10.1016/B978-0-12-809324-5.21110-3