TY - JOUR
T1 - Translational Control of Long-Lasting Synaptic Plasticity and Memory
AU - Costa-Mattioli, Mauro
AU - Sossin, Wayne S.
AU - Klann, Eric
AU - Sonenberg, Nahum
N1 - Funding Information:
We are grateful to Michael Sutton for comments on this manuscript, and we apologize to those whose data were not discussed due to space limitations. This work was supported by grants from Canadian Institute of Health (CIHR) to N.S., W.S.S., and M.C.-M. and National Institute of Health (NIH) to E.K. N.S. is a Howard Hughes Medical Institute (HHMI) International scholar.
PY - 2009/1/15
Y1 - 2009/1/15
N2 - Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits and thus long-term modifications in behavior. Translational control is important for regulating both general protein synthesis and synthesis of specific proteins in response to neuronal activity. In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases.
AB - Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits and thus long-term modifications in behavior. Translational control is important for regulating both general protein synthesis and synthesis of specific proteins in response to neuronal activity. In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases.
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U2 - 10.1016/j.neuron.2008.10.055
DO - 10.1016/j.neuron.2008.10.055
M3 - Review article
C2 - 19146809
AN - SCOPUS:58149469090
SN - 0896-6273
VL - 61
SP - 10
EP - 26
JO - Neuron
JF - Neuron
IS - 1
ER -