Translocation and activation of Rac in the hippocampus during associative contextual fear learning

Luis A. Martinez, Eric Klann, Maria V. Tejada-Simon

Research output: Contribution to journalArticle

Abstract

Small G proteins including Rac are mediators of changes in neuronal morphology associated with synaptic plasticity. Previous studies in our laboratory showed that Rac is highly expressed in the adult mouse hippocampus, a brain area that exhibits robust synaptic plasticity and is crucial for the acquisition of memories. In this study, we investigated whether Rac was involved in NMDA receptor-dependent associative fear learning in the area CA1 of adult mouse hippocampus. We found that Rac translocation and activation was increased in the hippocampus following associative fear conditioning in mice, and that these increases are blocked by intraperitoneal injection of the NMDA receptor channel blocker MK801 at the acquisition stage. Our data indicate that NMDA receptor-dependent associative fear learning alters Rac localization and function in the mouse hippocampus.

Original languageEnglish (US)
Pages (from-to)104-113
Number of pages10
JournalNeurobiology of Learning and Memory
Volume88
Issue number1
DOIs
StatePublished - Jul 2007

Keywords

  • Context fear
  • Hippocampus
  • Learning and memory
  • MK-801
  • Small GTPases

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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