Trapping a folding intermediate of the α-helix: Stabilization of the π-helix

Ross Chapman, John L. Kulp, Anupam Patgiri, Neville R. Kallenbach, Clay Bracken, Paramjit S. Arora

Research output: Contribution to journalArticlepeer-review


We report the design, synthesis, and characterization of a short peptide trapped in a π-helix configuration. This high-energy conformation was nucleated by a preorganized π-turn, which was obtained by replacing an N-terminal intramolecular main chain i and i + 5 hydrogen bond with a carbon-carbon bond. Our studies highlight the nucleation parameter as a key factor contributing to the relative instability of the π-helix and allow us to estimate fundamental helix-coil transition parameters for this conformation.

Original languageEnglish (US)
Pages (from-to)4189-4195
Number of pages7
Issue number14
StatePublished - Apr 8 2008

ASJC Scopus subject areas

  • Biochemistry


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