Treating periodontal diseases by blocking tissue-destructive enzymes.

L. M. Golub, M. Wolff, S. Roberts, H. M. Lee, M. Leung, G. S. Payonk

Research output: Contribution to journalArticlepeer-review


A new therapeutic approach involves the discovery by the "Stony Brook group," that tetracyclines, but not other antibiotics, can inhibit host-derived collagen-destructive enzymes. This newly discovered property of tetracyclines is unrelated to the antimicrobial activity of these drugs. Examples support the hypothesis that this unexpected property of tetracyclines provides a new approach to treating periodontal diseases as well as a variety of medical disorders.

Original languageEnglish (US)
Pages (from-to)163-169; discussion 169-171
JournalJournal of the American Dental Association (1939)
Issue number2
StatePublished - Feb 1994

ASJC Scopus subject areas

  • General Dentistry


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