Treating periodontal diseases by blocking tissue-destructive enzymes.

L. M. Golub; M. Wolff; S. Roberts; H. M. Lee; M. Leung; G. S. Payonk

doi:10.14219/jada.archive.1994.0261

Treating periodontal diseases by blocking tissue-destructive enzymes.

L. M. Golub, M. Wolff, S. Roberts, H. M. Lee, M. Leung, G. S. Payonk

Cariology and Comprehensive Care

Research output: Contribution to journal › Article › peer-review

Abstract

A new therapeutic approach involves the discovery by the "Stony Brook group," that tetracyclines, but not other antibiotics, can inhibit host-derived collagen-destructive enzymes. This newly discovered property of tetracyclines is unrelated to the antimicrobial activity of these drugs. Examples support the hypothesis that this unexpected property of tetracyclines provides a new approach to treating periodontal diseases as well as a variety of medical disorders.

Original language	English (US)
Pages (from-to)	163-169; discussion 169-171
Journal	Journal of the American Dental Association (1939)
Volume	125
Issue number	2
DOIs	https://doi.org/10.14219/jada.archive.1994.0261
State	Published - Feb 1994

ASJC Scopus subject areas

Dentistry(all)

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10.14219/jada.archive.1994.0261

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AU - Leung, M.

AU - Payonk, G. S.

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Treating periodontal diseases by blocking tissue-destructive enzymes.

Abstract

ASJC Scopus subject areas

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