Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study

Theodore B. VanItallie, C. Nonas, A. Di Rocco, K. Boyar, K. Hyams, S. B. Heymsfield

Research output: Contribution to journalArticle

Abstract

Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. Unified Parkinson's Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out.

Original languageEnglish (US)
Pages (from-to)728-730
Number of pages3
JournalNeurology
Volume64
Issue number4
DOIs
StatePublished - Feb 22 2005

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ASJC Scopus subject areas

  • Clinical Neurology

Cite this

VanItallie, T. B., Nonas, C., Di Rocco, A., Boyar, K., Hyams, K., & Heymsfield, S. B. (2005). Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study. Neurology, 64(4), 728-730. https://doi.org/10.1212/01.WNL.0000152046.11390.45