Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study

Theodore B. VanItallie; C. Nonas; A. Di Rocco; K. Boyar; K. Hyams; S. B. Heymsfield

doi:10.1212/01.WNL.0000152046.11390.45

Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study

Theodore B. VanItallie, C. Nonas, A. Di Rocco, K. Boyar, K. Hyams, S. B. Heymsfield

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Abstract

Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. Unified Parkinson's Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out.

Original language	English (US)
Pages (from-to)	728-730
Number of pages	3
Journal	Neurology
Volume	64
Issue number	4
DOIs	https://doi.org/10.1212/01.WNL.0000152046.11390.45
State	Published - Feb 22 2005

ASJC Scopus subject areas

Clinical Neurology

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10.1212/01.WNL.0000152046.11390.45

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AU - VanItallie, Theodore B.

AU - Nonas, C.

AU - Di Rocco, A.

AU - Boyar, K.

AU - Hyams, K.

AU - Heymsfield, S. B.

PY - 2005/2/22

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AB - Ketones may bypass the defect in complex I activity implicated in Parkinson disease (PD). Five of seven volunteers with PD were able to prepare a "hyperketogenic" diet at home and adhere to it for 28 days. Substituting unsaturated for saturated fats appeared to prevent cholesterol increases in four volunteers. Unified Parkinson's Disease Rating Scale scores improved in all five during hyperketonemia, but a placebo effect was not ruled out.

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Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study

Abstract

ASJC Scopus subject areas

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