Triglyceride-mimetic structure-gated prodrug nanoparticles for smart cancer therapy

Chutong Tian, Jingjing Guo, Yifan Miao, Shunzhe Zheng, Bingjun Sun, Mengchi Sun, Qing Ye, Wenxue Liu, Shuang Zhou, Ken Ichiro Kamei, Zhonggui He, Jin Sun

Research output: Contribution to journalArticlepeer-review


Off-target drug release and insufficient drug delivery are the main obstacles for effective anticancer chemotherapy. Prodrug-based self-assembled nanoparticles bioactivated under tumor-specific conditions are one of the effective strategies to achieve on-demand drug release and effective tumor accumulation. Herein, stimuli-activable prodrugs are designed yielding smart tumor delivery by combination of the triglyceride-mimic (TG-mimetic) prodrug structure and disulfide bond. Surprisingly, these prodrugs can self-assemble into uniform nanoparticles (NPs) with a high drug loading (over 40%) and accumulate in tumor sites specifically. The super hydrophobic TG structure can act as a gate that senses lipase to selectively control over NP dissociation and affect the glutathione-triggered prodrug activation. In addition, the impacts of the double bonds in the prodrug NPs on parent drug release and the following cytotoxicity, pharmacokinetics, and antitumor efficiency are further demonstrated. Our findings highlight the promising potential of TG-mimetic structure-gated prodrug nanoparticles for tumor-specific drug delivery.

Original languageEnglish (US)
Pages (from-to)15936-15948
Number of pages13
JournalJournal of Medicinal Chemistry
Issue number21
StatePublished - Nov 11 2021

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


Dive into the research topics of 'Triglyceride-mimetic structure-gated prodrug nanoparticles for smart cancer therapy'. Together they form a unique fingerprint.

Cite this