Trophic interactions between brain-derived neurotrophic factor and S100β on cultured serotonergic neurons

Mayumi Nishi, Mitsuhiro Kawata, Efrain C. Azmitia

Research output: Contribution to journalArticle

Abstract

Brain-derived neurotrophic factor (BDNF) and S100β stimulate serotonergic neurons in fetal rat raphe primary cultures grown under serum- free conditions. BDNF (50 ng/ml) treatment for 3 h enhanced S100β immunoreactivity in both raphe and hippocampal glial cells. Combined treatment with BDNF and S100β for 3 days increased the soma area of 5-HT neurons, but not the neurite length. Our results suggest that BDNF and S100β, which regulate different signal transduction cascades, interact to exert complimentary effects on neuronal maturation by acting sequentially, not concurrently. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalBrain Research
Volume868
Issue number1
DOIs
StatePublished - Jun 16 2000

Keywords

  • BDNF
  • MAP kinase
  • Neuronal-glial interaction
  • Raphe
  • Tissue culture

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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