Tumor-induced structural and radiometric asymmetry in brain images

Peter Lorenzen, Sarang Joshi, Guido Gerig, Elizabeth Bullitt

Research output: Contribution to conferencePaperpeer-review


This paper presents a general framework for analyzing structural and radiometric asymmetry in brain images. In a healthy brain, the left and right hemispheres are largely symmetric across the mid-sagittal plane. Brain tumors may belong to one or both of the following categories: mass-effect, in which the diseased tissue displaces healthy tissue; and infiltrating, in which healthy tissue has become diseased. Mass-effect brain tumors cause structural asymmetry by displacing healthy tissue, and may cause radiometric asymmetry in adjacent normal structures due to edema. Infiltrating tumors have a different radiometric response from healthy tissue. Thus, structural and radiometric asymmetries across the mid-sagittal plane in brain images provide important cues that tumors may be present. We have developed a framework that registers images with their reflections across the mid-sagittal plane. The registration process accounts for tissue displacement through large deformation image warping. Radiometric differences are taken into account through an additive intensity field. We present an efficient multi-scale algorithm for the joint estimation of structural and radiometric asymmetry.

Original languageEnglish (US)
Number of pages8
StatePublished - 2001
EventWorkshop on Mathematical Methods in Biomedical Image Analysis MMBIA 2001 - Kauai, HI, United States
Duration: Dec 9 2001Dec 10 2001


OtherWorkshop on Mathematical Methods in Biomedical Image Analysis MMBIA 2001
Country/TerritoryUnited States
CityKauai, HI


  • Brain symmetry analysis
  • Deformable image mapping
  • Medical image analysis
  • Plane of symmetry estimation

ASJC Scopus subject areas

  • Analysis


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