Two mechanisms of isoproterenol inhibition of smooth muscle

Norbert I.A. Overweg, Joel D. Schiff

Research output: Contribution to journalArticle

Abstract

The relaxation of depolarized ileal and uterine smooth muscle by isoproterenol was compared with that brought about by dibutyryl-cAMP and by other agents which increase cytoplasmic cAMP. Qualitative differences observed between the time courses of the relaxations imply the existence of a rapid β-adrenergic mechanism independent of cAMP as well as slower cAMP-dependent relaxation. This dual process model for β-adrenergic inhibition of smooth muscle is consistent with seemingly opposing published reports.

Original languageEnglish (US)
Pages (from-to)231-233
Number of pages3
JournalEuropean Journal of Pharmacology
Volume47
Issue number2
DOIs
StatePublished - Jan 15 1978

Keywords

  • Cyclic AMP
  • Isoproterenol
  • Phosphodiesterase inhibitors
  • Smooth muscle

ASJC Scopus subject areas

  • Pharmacology

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