Two mechanisms of isoproterenol inhibition of smooth muscle

Norbert I.A. Overweg; Joel D. Schiff

doi:10.1016/0014-2999(78)90395-3

Two mechanisms of isoproterenol inhibition of smooth muscle

Norbert I.A. Overweg, Joel D. Schiff

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

The relaxation of depolarized ileal and uterine smooth muscle by isoproterenol was compared with that brought about by dibutyryl-cAMP and by other agents which increase cytoplasmic cAMP. Qualitative differences observed between the time courses of the relaxations imply the existence of a rapid β-adrenergic mechanism independent of cAMP as well as slower cAMP-dependent relaxation. This dual process model for β-adrenergic inhibition of smooth muscle is consistent with seemingly opposing published reports.

Original language	English (US)
Pages (from-to)	231-233
Number of pages	3
Journal	European Journal of Pharmacology
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/0014-2999(78)90395-3
State	Published - Jan 15 1978

Keywords

Cyclic AMP
Isoproterenol
Phosphodiesterase inhibitors
Smooth muscle

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(78)90395-3

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AU - Schiff, Joel D.

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AB - The relaxation of depolarized ileal and uterine smooth muscle by isoproterenol was compared with that brought about by dibutyryl-cAMP and by other agents which increase cytoplasmic cAMP. Qualitative differences observed between the time courses of the relaxations imply the existence of a rapid β-adrenergic mechanism independent of cAMP as well as slower cAMP-dependent relaxation. This dual process model for β-adrenergic inhibition of smooth muscle is consistent with seemingly opposing published reports.

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KW - Isoproterenol

KW - Phosphodiesterase inhibitors

KW - Smooth muscle

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Two mechanisms of isoproterenol inhibition of smooth muscle

Abstract

Keywords

ASJC Scopus subject areas

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