@article{948c0e94c74e4aefa1fd374a31301b82,
title = "Two-Photon, Ratiometric, Quantitative Fluorescent Probe Reveals Fluctuation of Peroxynitrite Regulated by Arginase 1",
abstract = "Peroxynitrite, a transient reactive oxygen species (ROS), is believed to play a deleterious role in physiological processes. Herein, we report a two-photon ratiometric fluorescent probe that selectively reacts with peroxynitrite yielding a >200-fold change upon reaction. The probe effectively visualized fluctuations in peroxynitrite generation by arginase 1 in vivo and in vitro. This provides evidence that arginase 1 is a critical regulator of peroxynitrite. ",
author = "Shiyu Chen and Beyza Vurusaner and Stephanie Pena and Thu, {Chu T.} and Lara Mahal and Fisher, {Edward A.} and Canary, {James W.}",
note = "Funding Information: This work was supported by NSF grant CHE-1412568 and NIH grant HL084312. The authors appreciate assistance from research scientist Dr. Michael Cammer in NYU Langone{\textquoteright}s Microscopy Laboratory and the generous provision of the ApoB ASO by Ionis Pharmaceuticals. Microscopy shared resource is partially supported by the Cancer Center Support Grant P30CA016087 at the Laura and Isaac Perlmutter Cancer Center. Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",
year = "2021",
month = jul,
day = "27",
doi = "10.1021/acs.analchem.1c00911",
language = "English (US)",
volume = "93",
pages = "10090--10098",
journal = "Analytical Chemistry",
issn = "0003-2700",
number = "29",
}