Two related families of retrotransposons from Schizosaccharomyces pombe

H. L. Levin, D. C. Weaver, J. D. Boeke

    Research output: Contribution to journalArticle

    Abstract

    Two related families of transposons were isolated from Schizosaccharomyces pombe, an organism which has been the object of extensive genetic studies which had previously produced no evidence for the existence of such elements. These two classes of repeated DNAs, dubbed Tf1 (transposon of fission yeast 1) and Tf2 have many properties of retrotransposons. Tf1 and Tf2 both possess long terminal repeats and predicted protein sequences that resemble the protease, reverse transcriptase, and integrase domains of retroviruses. The chromosomal locations and total numbers of Tf1 and Tf2 differ greatly in various isolates of S. pombe. The Tf elements are expressed in the form of 4.5-kb mRNAs. The complete sequence of Tf1 was determined and suggests that a novel mechanism for regulating its gene expression may be used.

    Original languageEnglish (US)
    Pages (from-to)6791-6798
    Number of pages8
    JournalMolecular and cellular biology
    Volume10
    Issue number12
    DOIs
    StatePublished - 1990

    ASJC Scopus subject areas

    • Molecular Biology
    • Cell Biology

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