TY - JOUR
T1 - Two-step tuberculin skin testing in drug users
AU - Swaminathan, Shobha
AU - Schoenbaum, Ellie E.
AU - Klein, Robert S.
AU - Howard, Andrea A.
AU - Lo, Yungtai
AU - Gourevitch, Marc N.
PY - 2007/5/24
Y1 - 2007/5/24
N2 - To assess the utility of booster testing and to identify factors associated with a positive booster test, two-step tuberculin testing was performed in drug users recruited from methadone treatment. Participants also received a standardized interview on demographics and testing for HIV and CD4+ lymphocyte count. Of 619 enrollees completing the protocol, 174 (28%) had a positive PPD and 24 of the remaining 445 (5%) had a positive booster test. On multivariate analysis, boosting was associated with older age (adjusted odds ratio [ORadj] 2.38/decade, 95% confidence interval [CI] 1.34-4.22), history of using crack cocaine (ORadj 2.61, 95% CI 1.10-6.18) and a history of working as a home health aide (ORadj 4.23, 95% CI 1.39-12.86). Two-step tuberculin skin testing increased the proportion of participants with latent tuberculosis infection from 22% to 25%. Given the effectiveness of chemoprophylaxis, booster testing should be considered when drug users are screened for tuberculosis infection.
AB - To assess the utility of booster testing and to identify factors associated with a positive booster test, two-step tuberculin testing was performed in drug users recruited from methadone treatment. Participants also received a standardized interview on demographics and testing for HIV and CD4+ lymphocyte count. Of 619 enrollees completing the protocol, 174 (28%) had a positive PPD and 24 of the remaining 445 (5%) had a positive booster test. On multivariate analysis, boosting was associated with older age (adjusted odds ratio [ORadj] 2.38/decade, 95% confidence interval [CI] 1.34-4.22), history of using crack cocaine (ORadj 2.61, 95% CI 1.10-6.18) and a history of working as a home health aide (ORadj 4.23, 95% CI 1.39-12.86). Two-step tuberculin skin testing increased the proportion of participants with latent tuberculosis infection from 22% to 25%. Given the effectiveness of chemoprophylaxis, booster testing should be considered when drug users are screened for tuberculosis infection.
KW - Drug users
KW - Skin testing
KW - Tuberculosis
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U2 - 10.1300/J069v26n02_09
DO - 10.1300/J069v26n02_09
M3 - Article
C2 - 17595000
AN - SCOPUS:34548418931
VL - 26
SP - 71
EP - 79
JO - Journal of Addictive Diseases
JF - Journal of Addictive Diseases
SN - 1055-0887
IS - 2
ER -