TY - JOUR
T1 - Tyrosine kinases, synaptic plasticity and memory
T2 - Insights from vertebrates and invertebrates
AU - Purcell, Angela L.
AU - Carew, Thomas J.
PY - 2003/11
Y1 - 2003/11
N2 - Tyrosine kinases were first characterized in terms of their function during development. Over the past decade, it has become clear that tyrosine phosphorylation also plays an important role in the adult mammalian nervous system. This article reviews three different families of tyrosine kinase signaling cascades: the Trk receptor tyrosine kinases, the Src family of non-receptor tyrosine kinases and the Eph receptor tyrosine kinases. Each of these cascades has been implicated in both adult synaptic plasticity and memory formation. Evidence from invertebrate systems also demonstrates a role for tyrosine kinase signaling in the induction of long-term memory, suggesting that molecular mechanisms of memory formation are conserved across species.
AB - Tyrosine kinases were first characterized in terms of their function during development. Over the past decade, it has become clear that tyrosine phosphorylation also plays an important role in the adult mammalian nervous system. This article reviews three different families of tyrosine kinase signaling cascades: the Trk receptor tyrosine kinases, the Src family of non-receptor tyrosine kinases and the Eph receptor tyrosine kinases. Each of these cascades has been implicated in both adult synaptic plasticity and memory formation. Evidence from invertebrate systems also demonstrates a role for tyrosine kinase signaling in the induction of long-term memory, suggesting that molecular mechanisms of memory formation are conserved across species.
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U2 - 10.1016/j.tins.2003.09.005
DO - 10.1016/j.tins.2003.09.005
M3 - Review article
C2 - 14585603
AN - SCOPUS:0242285659
VL - 26
SP - 625
EP - 630
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 11
ER -