Tyrosine oxidation products: Analysis and biological relevance

C. Giulivi, N. J. Traaseth, K. J.A. Davies

Research output: Contribution to journalReview article

Abstract

Dityrosine is found in several proteins as a product of UV irradiation, γ-irradiation, aging, exposure to oxygen free radicals, nitrogen dioxide, peroxynitrite, and lipid hydroperoxides. Interest of dityrosine in proteins is based on its potential as a specific marker for oxidatively damaged proteins and their selective proteolysis, hence it could be used as a marker for oxidative stress. Dityrosine is also the product of normal post-translational processes affecting specific structural proteins. Since post-translational modification of a given amino acid in a protein is equivalent to the substitution of that residue by an analogue, it has been proposed that the covalent modification of amino acids may serve as a "marking" step for protein degradation.

Original languageEnglish (US)
Pages (from-to)227-232
Number of pages6
JournalAmino Acids
Volume25
Issue number3-4
DOIs
StatePublished - Dec 2003

Keywords

  • Dityrosine
  • Oxidative stress
  • Oxygen free radicals
  • Protein damage
  • Proteolysis

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

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