Ultrahigh resolution optical coherence tomography for enhanced visualization of retinal pathology

Tony Ko, Wolfgang Drexler, Lelia Adelina Paunescu, Ingmar Hartl, Ravi Ghanta, Joel Schuman, James Fujimoto

Research output: Contribution to journalConference articlepeer-review


An ultrahigh resolution ophthalmic optical coherence tomography (OCT) system has been developed. Using a femtosecond Ti:sapphire laser light source, which generates bandwidths of ∼150 nm at 800 nm, real-time, cross-sectional imaging of the retina with ∼3 μm axial resolution is possible. Ultrahigh resolution OCT images of retinal morphology were obtained in normal subjects and patients with retinal disease. Intraretinal architectural morphology associated with macular diseases such as macular edema, epiretinal membranes, and macular holes can be visualized with unprecedented resolution. Ultrahigh resolution ophthalmic OCT promises to improve the early diagnosis of retinal diseases as well as enable monitoring of disease progression and the efficacy of therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)55-58
Number of pages4
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2003
EventPROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII - San Jose, CA, United States
Duration: Jan 27 2003Jan 29 2003

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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