Ultrasensitive nanoparticle detection using a portable whispering gallery mode biosensor driven by a periodically poled lithium-niobate frequency doubled distributed feedback laser

S. I. Shopova; R. Rajmangal; Y. Nishida; S. Arnold

doi:10.1063/1.3499261

Ultrasensitive nanoparticle detection using a portable whispering gallery mode biosensor driven by a periodically poled lithium-niobate frequency doubled distributed feedback laser

S. I. Shopova, R. Rajmangal, Y. Nishida, S. Arnold

Research output: Contribution to journal › Article › peer-review

Abstract

We demonstrate a significant reduction in the limit of label-free detection of individual viral-sized nanoparticles in aqueous solution through the use of a frequency doubled telecom laser constructed from a distributed feedback-periodically poled lithium-niobate (DFB-PPLN) union. By driving a whispering gallery mode biosensor near a wavelength of 650 nm with this device we have detected real-time adsorption steps for particles 36 nm in radius with a signal to noise ratio of 8. The noise equivalent detection limit is ∼20 ag (17 nm radius). This new lower limit is attributed to the ultralow resonance wavelength noise [(Δ λ_r) rms / λ_r < 10^-9] associated with the use of the DFB-PPLN device.

Original language	English (US)
Article number	103110
Journal	Review of Scientific Instruments
Volume	81
Issue number	10
DOIs	https://doi.org/10.1063/1.3499261
State	Published - Oct 2010

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Instrumentation

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10.1063/1.3499261

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Ultrasensitive nanoparticle detection using a portable whispering gallery mode biosensor driven by a periodically poled lithium-niobate frequency doubled distributed feedback laser. / Shopova, S. I.; Rajmangal, R.; Nishida, Y. et al.
In: Review of Scientific Instruments, Vol. 81, No. 10, 103110, 10.2010.

Research output: Contribution to journal › Article › peer-review

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title = "Ultrasensitive nanoparticle detection using a portable whispering gallery mode biosensor driven by a periodically poled lithium-niobate frequency doubled distributed feedback laser",

abstract = "We demonstrate a significant reduction in the limit of label-free detection of individual viral-sized nanoparticles in aqueous solution through the use of a frequency doubled telecom laser constructed from a distributed feedback-periodically poled lithium-niobate (DFB-PPLN) union. By driving a whispering gallery mode biosensor near a wavelength of 650 nm with this device we have detected real-time adsorption steps for particles 36 nm in radius with a signal to noise ratio of 8. The noise equivalent detection limit is ∼20 ag (17 nm radius). This new lower limit is attributed to the ultralow resonance wavelength noise [(Δ λr) rms / λr < 10-9] associated with the use of the DFB-PPLN device.",

author = "Shopova, {S. I.} and R. Rajmangal and Y. Nishida and S. Arnold",

note = "Funding Information: The authors want to thank NEL for the loan of PPLN device and the National Science Foundation for supporting this work (Grant No. CBET 0933531). ",

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AU - Arnold, S.

N1 - Funding Information: The authors want to thank NEL for the loan of PPLN device and the National Science Foundation for supporting this work (Grant No. CBET 0933531).

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Ultrasensitive nanoparticle detection using a portable whispering gallery mode biosensor driven by a periodically poled lithium-niobate frequency doubled distributed feedback laser

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