Understanding parathyroid hormone action

Nicola C. Partridge; Xin Li; Ling Qin

doi:10.1196/annals.1346.024

Understanding parathyroid hormone action

Nicola C. Partridge, Xin Li, Ling Qin

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

In addition to regulating serum calcium and stimulating bone resorption, parathyroid hormone (PTH) is known to stimulate bone formation under certain conditions. The mechanisms behind this counterintuitive anabolic action are largely unknown. We have set out to identify PTH-regulated genes that might be responsible for each of these contrasting effects of the hormone. This article describes our work on a select number of those genes.

Original language	English (US)
Pages (from-to)	187-193
Number of pages	7
Journal	Annals of the New York Academy of Sciences
Volume	1068
Issue number	1
DOIs	https://doi.org/10.1196/annals.1346.024
State	Published - Apr 2006

Keywords

Amphiregulin
Bone formation
Bone resorption
EGF
MCP-1
Osteoblast
PTH
Parathyroid hormone

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

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10.1196/annals.1346.024

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AB - In addition to regulating serum calcium and stimulating bone resorption, parathyroid hormone (PTH) is known to stimulate bone formation under certain conditions. The mechanisms behind this counterintuitive anabolic action are largely unknown. We have set out to identify PTH-regulated genes that might be responsible for each of these contrasting effects of the hormone. This article describes our work on a select number of those genes.

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KW - MCP-1

KW - Osteoblast

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Understanding parathyroid hormone action

Abstract

Keywords

ASJC Scopus subject areas

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