Universal protein distributions in a model of cell growth and division

Naama Brenner, C. M. Newman, Dino Osmanovic, Yitzhak Rabin, Hanna Salman, D. L. Stein

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Protein distributions measured under a broad set of conditions in bacteria and yeast were shown to exhibit a common skewed shape, with variances depending quadratically on means. For bacteria these properties were reproduced by temporal measurements of protein content, showing accumulation and division across generations. Here we present a stochastic growth-and-division model with feedback which captures these observed properties. The limiting copy number distribution is calculated exactly, and a single parameter is found to determine the distribution shape and the variance-to-mean relation. Estimating this parameter from bacterial temporal data reproduces the measured distribution shape with high accuracy, and leads to predictions for future experiments.
Original languageUndefined
Article number1504.02139
StatePublished - Apr 8 2015


  • physics.bio-ph
  • q-bio.SC

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