This study addresses the gap in knowledge about differences in how instructors use analytics to inform teaching by examining the ways that thirteen college instructors engaged with a set of university-provided analytics. Using multiple walk-through interviews with the instructors and qualitative inductive coding, two profiles of instructor analytics use were identified that were distinct from each other in terms of the goals of analytics use, how instructors made sense of and took actions upon the analytics, and the ways that ethical concerns were conceived. Specifically, one group of instructors used analytics to help students get aligned to and engaged in the course, whereas the other group used analytics to align the course to meet students' needs. Instructors in both profiles saw ethical questions as central to their learning analytics use, with instructors in one profile focusing on transparency and the other on student privacy and agency. These findings suggest the need to view analytics use as an integrated component of instructor teaching practices and envision complementary sets of technical and pedagogical support that can best facilitate the distinct activities aligned with each profile.