Unprecedented sodium-oxygen clusters in the solid-state structure of trisodium hydrogentetravalproate monohydrate: A model for the physiological activity of the anticonvulsant drug Epilim®

Gjorgi Petruševski; Panče Naumov; Gligor Jovanovski; Seik Weng Ng

doi:10.1016/j.inoche.2007.10.024

Unprecedented sodium-oxygen clusters in the solid-state structure of trisodium hydrogentetravalproate monohydrate: A model for the physiological activity of the anticonvulsant drug Epilim^®

Gjorgi Petruševski, Panče Naumov, Gligor Jovanovski, Seik Weng Ng

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

The first crystal structure determination of one of the solid forms of sodium valproate revealed that the crystal is a 3:1 solvate of sodium valproate and valproic acid. The anion symmetry-directed formation of stable sodium-oxygen clusters protected by alkyl layer which can act as lipophilic micelles may be important for understanding the strong anticonvulsant activity of the valproate ion.

Original language	English (US)
Pages (from-to)	81-84
Number of pages	4
Journal	Inorganic Chemistry Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1016/j.inoche.2007.10.024
State	Published - Jan 2008

Keywords

Anticonvulsants
Bilayers
Clusters
Epilim
Hydrates
Hygroscopicity

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

Access to Document

10.1016/j.inoche.2007.10.024

Cite this

Unprecedented sodium-oxygen clusters in the solid-state structure of trisodium hydrogentetravalproate monohydrate: A model for the physiological activity of the anticonvulsant drug Epilim^®. / Petruševski, Gjorgi; Naumov, Panče; Jovanovski, Gligor et al.
In: Inorganic Chemistry Communications, Vol. 11, No. 1, 01.2008, p. 81-84.

Research output: Contribution to journal › Article › peer-review

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