The first crystal structure determination of one of the solid forms of sodium valproate revealed that the crystal is a 3:1 solvate of sodium valproate and valproic acid. The anion symmetry-directed formation of stable sodium-oxygen clusters protected by alkyl layer which can act as lipophilic micelles may be important for understanding the strong anticonvulsant activity of the valproate ion.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Inorganic Chemistry
- Materials Chemistry