Unreliable Evoked Responses in Autism

Ilan Dinstein, David J. Heeger, Lauren Lorenzi, Nancy J. Minshew, Rafael Malach, Marlene Behrmann

Research output: Contribution to journalArticlepeer-review

Abstract

Autism has been described as a disorder of general neural processing, but the particular processing characteristics that might be abnormal in autism have mostly remained obscure. Here, we present evidence of one such characteristic: poor evoked response reliability. We compared cortical response amplitude and reliability (consistency across trials) in visual, auditory, and somatosensory cortices of high-functioning individuals with autism and controls. Mean response amplitudes were statistically indistinguishable across groups, yet trial-by-trial response reliability was significantly weaker in autism, yielding smaller signal-to-noise ratios in all sensory systems. Response reliability differences were evident only in evoked cortical responses and not in ongoing resting-state activity. These findings reveal that abnormally unreliable cortical responses, even to elementary nonsocial sensory stimuli, may represent a fundamental physiological alteration of neural processing in autism. The results motivate a critical expansion of autism research to determine whether (and how) basic neural processing properties such as reliability, plasticity, and adaptation/habituation are altered in autism.

Original languageEnglish (US)
Pages (from-to)981-991
Number of pages11
JournalNeuron
Volume75
Issue number6
DOIs
StatePublished - Sep 20 2012

ASJC Scopus subject areas

  • Neuroscience(all)

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