TY - JOUR
T1 - Updating of aversive memories after temporal error detection is differentially modulated by mTOR across development
AU - Tallot, Lucille
AU - Diaz-Mataix, Lorenzo
AU - Perry, Rosemarie E.
AU - Wood, Kira
AU - LeDoux, Joseph E.
AU - Mouly, Anne Marie
AU - Sullivan, Regina M.
AU - Doyère, Valérie
N1 - Funding Information:
This research was supported by the following grants: Fulbright (L.T.), CNRS-NYU LIA LearnEmoTime (V.D., R.M.S., A.-M.M., J.E.L), PUF Emotion and Timing (V.D., R.M.S., A.-M.M., J.E.L.), ANR grants (V.D.), NARSAD Young Investigator grant (L.D.M), LABEX CORTEX of Universit? de Lyon (A.-M.M), and NIH MH091451, HD083217 (R.M.S.). We thank Guillaume Ferreira for his helpful input on the results.
Publisher Copyright:
© 2017 Tallot et al.
PY - 2017/3
Y1 - 2017/3
N2 - The updating of a memory is triggered whenever it is reactivated and a mismatch from what is expected (i.e., prediction error) is detected, a process that can be unraveled through the memory's sensitivity to protein synthesis inhibitors (i.e., reconsolidation). As noted in previous studies, in Pavlovian threat/aversive conditioning in adult rats, prediction error detection and its associated protein synthesis-dependent reconsolidation can be triggered by reactivating the memory with the conditioned stimulus (CS), but without the unconditioned stimulus (US), or by presenting a CS-US pairing with a different CS-US interval than during the initial learning. Whether similar mechanisms underlie memory updating in the young is not known. Using similar paradigms with rapamycin (an mTORC1 inhibitor), we show that preweaning rats (PN18-20) do form a long-term memory of the CS-US interval, and detect a 10-sec versus 30-sec temporal prediction error. However, the resulting updating/reconsolidation processes become adult-like after adolescence (PN30-40). Our results thus show that while temporal prediction error detection exists in preweaning rats, specific infant-type mechanisms are at play for associative learning and memory.
AB - The updating of a memory is triggered whenever it is reactivated and a mismatch from what is expected (i.e., prediction error) is detected, a process that can be unraveled through the memory's sensitivity to protein synthesis inhibitors (i.e., reconsolidation). As noted in previous studies, in Pavlovian threat/aversive conditioning in adult rats, prediction error detection and its associated protein synthesis-dependent reconsolidation can be triggered by reactivating the memory with the conditioned stimulus (CS), but without the unconditioned stimulus (US), or by presenting a CS-US pairing with a different CS-US interval than during the initial learning. Whether similar mechanisms underlie memory updating in the young is not known. Using similar paradigms with rapamycin (an mTORC1 inhibitor), we show that preweaning rats (PN18-20) do form a long-term memory of the CS-US interval, and detect a 10-sec versus 30-sec temporal prediction error. However, the resulting updating/reconsolidation processes become adult-like after adolescence (PN30-40). Our results thus show that while temporal prediction error detection exists in preweaning rats, specific infant-type mechanisms are at play for associative learning and memory.
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U2 - 10.1101/lm.043083.116
DO - 10.1101/lm.043083.116
M3 - Article
C2 - 28202715
AN - SCOPUS:85013626857
VL - 24
SP - 115
EP - 122
JO - Learning and Memory
JF - Learning and Memory
SN - 1072-0502
IS - 3
ER -