TY - JOUR
T1 - Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control
AU - Dallérac, Glenn
AU - Graupner, Michael
AU - Knippenberg, Jeroen
AU - Martinez, Raquel Chacon Ruiz
AU - Tavares, Tatiane Ferreira
AU - Tallot, Lucille
AU - El Massioui, Nicole
AU - Verschueren, Anna
AU - Höhn, Sophie
AU - Bertolus, Julie Boulanger
AU - Reyes, Alex
AU - LeDoux, Joseph E.
AU - Schafe, Glenn E.
AU - Diaz-Mataix, Lorenzo
AU - Doyère, Valerie
N1 - Publisher Copyright:
© The Author(s) 2017.
PY - 2017/1/9
Y1 - 2017/1/9
N2 - Pavlovian aversive conditioning requires learning of the association between a conditioned stimulus (CS) and an unconditioned, aversive stimulus (US) but also involves encoding the time interval between the two stimuli. The neurobiological bases of this time interval learning are unknown. Here, we show that in rats, the dorsal striatum and basal amygdala belong to a common functional network underlying temporal expectancy and learning of a CS-US interval. Importantly, changes in coherence between striatum and amygdala local field potentials (LFPs) were found to couple these structures during interval estimation within the lower range of the theta rhythm (3-6 Hz). Strikingly, we also show that a change to the CS-US time interval results in long-term changes in cortico-striatal synaptic efficacy under the control of the amygdala. Collectively, this study reveals physiological correlates of plasticity mechanisms of interval timing that take place in the striatum and are regulated by the amygdala.
AB - Pavlovian aversive conditioning requires learning of the association between a conditioned stimulus (CS) and an unconditioned, aversive stimulus (US) but also involves encoding the time interval between the two stimuli. The neurobiological bases of this time interval learning are unknown. Here, we show that in rats, the dorsal striatum and basal amygdala belong to a common functional network underlying temporal expectancy and learning of a CS-US interval. Importantly, changes in coherence between striatum and amygdala local field potentials (LFPs) were found to couple these structures during interval estimation within the lower range of the theta rhythm (3-6 Hz). Strikingly, we also show that a change to the CS-US time interval results in long-term changes in cortico-striatal synaptic efficacy under the control of the amygdala. Collectively, this study reveals physiological correlates of plasticity mechanisms of interval timing that take place in the striatum and are regulated by the amygdala.
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U2 - 10.1038/ncomms13920
DO - 10.1038/ncomms13920
M3 - Article
C2 - 28067224
AN - SCOPUS:85009094273
SN - 2041-1723
VL - 8
JO - Nature communications
JF - Nature communications
M1 - 13920
ER -