Abstract
There is increasing recognition of the importance of the distinction between efficacy and effectiveness research in the design, conduct, and evaluation of interventions and program outcomes. There is a concurrent increase in the application of systematic reviews and meta-analyses. These two lines of inquiry are only beginning to meet. There is an emerging need for systematic reviews and meta-analyses to account for differences in degrees to which included studies reflect either efficacy or effectiveness design. Based on ongoing work on a formal systematic review of the hepatitis C virus care continuum, this paper describes and discusses the rationale for, and how the PRECIS-II instrument can be used on, and modestly adapted to, studies included in the systematic review examining the extent to which studies include elements of efficacy or effectiveness or a combination of the two. We also highlight that use of such an instrument may have general applicability to and value in the conduct of systematic reviews and meta-analysis.
Original language | English (US) |
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Pages (from-to) | 66-75 |
Number of pages | 10 |
Journal | Journal of Clinical Epidemiology |
Volume | 93 |
DOIs | |
State | Published - Jan 2018 |
Keywords
- Care continua
- Effectiveness
- Efficacy
- Hepatitis C virus
- Meta-analyses
- PRECIS-II
- Systematic reviews
ASJC Scopus subject areas
- Epidemiology