Use of the PRECIS-II instrument to categorize reports along the efficacy-effectiveness spectrum in an hepatitis C virus care continuum systematic review and meta-analysis

Ashly E. Jordan, David C. Perlman, Daniel J. Smith, Jennifer R. Reed, Holly Hagan

Research output: Contribution to journalArticlepeer-review

Abstract

There is increasing recognition of the importance of the distinction between efficacy and effectiveness research in the design, conduct, and evaluation of interventions and program outcomes. There is a concurrent increase in the application of systematic reviews and meta-analyses. These two lines of inquiry are only beginning to meet. There is an emerging need for systematic reviews and meta-analyses to account for differences in degrees to which included studies reflect either efficacy or effectiveness design. Based on ongoing work on a formal systematic review of the hepatitis C virus care continuum, this paper describes and discusses the rationale for, and how the PRECIS-II instrument can be used on, and modestly adapted to, studies included in the systematic review examining the extent to which studies include elements of efficacy or effectiveness or a combination of the two. We also highlight that use of such an instrument may have general applicability to and value in the conduct of systematic reviews and meta-analysis.

Original languageEnglish (US)
Pages (from-to)66-75
Number of pages10
JournalJournal of Clinical Epidemiology
Volume93
DOIs
StatePublished - Jan 2018

Keywords

  • Care continua
  • Effectiveness
  • Efficacy
  • Hepatitis C virus
  • Meta-analyses
  • PRECIS-II
  • Systematic reviews

ASJC Scopus subject areas

  • Epidemiology

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