Using diffuse optical tomograpy to monitor tumor response to neoadjuvant chemotherapy in breast cancer patients

Jacqueline E. Gunther, Emerson Lim, Hyun Keol Kim, Molly Flexman, Mindy Brown, Susan Refrice, Kevin Kalinsky, Dawn Hershman, Andreas H. Hielscher

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Breast cancer patients often undergo neoadjuvant chemotherapy to reduce the size of the tumor before surgery. Tumors which demonstrate a pathologic complete response associate with improved disease-free survival; however, as low as 10% of patients may achieve this status. The goal is to predict response to anti-cancer therapy early, so as to develop personalized treatments and optimize the patient's results. Previous studies have shown that tumor response can be predicted within a few days of treatment initiation. We have developed a diffuse optical tomography (DOT) imaging system for monitoring the response of breast cancer patients to neoadjuvant chemotherapy. Our breast imaging system is a continuous wave system that uses four wavelengths in the near-infrared spectrum (765 nm, 808 nm, 827 nm, and 905 nm). Both breasts are imaged simultaneously with a total of 64 sources and 128 detectors. Three dimensional reconstructions for oxy-hemoglobin concentration ([HbO2]), deoxy-hemoglobin ([Hb]) concentrations, and water are performed using a PDE-constrained multispectral imaging method that uses the diffusion approximation as a model for light propagation. Each patient receives twelve weekly treatments of Taxane followed by four cycles of Doxorubicin and Cyclophosphamide (AC) given every other week. There are six DOT imaging time points: baseline, week 3 and 5 of Paclitaxel, before cycle 1 and 2 of AC, and before surgery. Preliminary results show that there is statistical significance for the percent change of [HbO2], [Hb], [HbT], and percent water at week 2 from the baseline between patients with a pathologic response to chemotherapy.

Original languageEnglish (US)
Title of host publicationOptical Tomography and Spectroscopy of Tissue X
StatePublished - 2013
EventOptical Tomography and Spectroscopy of Tissue X - San Francisco, CA, United States
Duration: Feb 3 2013Feb 6 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceOptical Tomography and Spectroscopy of Tissue X
Country/TerritoryUnited States
CitySan Francisco, CA


  • Breast Imaging
  • Diffuse Optical Tomography
  • Neoadjuvant Chemotherapy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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