Using Optimal Test Assembly Methods for Shortening Patient-Reported Outcome Measures: Development and Validation of the Cochin Hand Function Scale-6: A Scleroderma Patient-Centered Intervention Network Cohort Study

Alexander W. Levis, Daphna Harel, Linda Kwakkenbos, Marie Eve Carrier, Luc Mouthon, Serge Poiraudeau, Susan J. Bartlett, Dinesh Khanna, Vanessa L. Malcarne, Maureen Sauve, Cornelia H M van den Ende, Janet L. Poole, Anne A. Schouffoer, Joep Welling, Brett D. Thombs, Murray Baron, Carolyn Ells, Yeona Jang, Russell J. Steele, Dan FurstSuzanne Kafaja, Karen Gottesman, Frank van den Hoogen, Maureen D. Mayes, Shervin Assassi, Warren R. Nielson, Robert Riggs, Fredrick Wigley, Isabelle Boutron, Angela Costa Maia, Catarina Leite, Ghassan El-Baalbaki, Jennifer Persmann, Kim Fligelstone, Catherine Fortune, Karen Nielsen, Tracy Frech, Dominique Godard, Marie Hudson, Genevieve Gyger, Vanessa C. Delisle, Lisa R. Jewitt, Brooke Levis, Katherine Milette, Ann Impens, Sindhu R. Johnson, Ann Tyrell Kennedy, Maggie Larche, Nader Khalidi, Carlo Marra, and the Scleroderma Patient-Centered Intervention Network Investigators

Research output: Contribution to journalArticle

Abstract

Objective: To develop and validate a short form of the Cochin Hand Function Scale (CHFS), which measures hand disability, for use in systemic sclerosis, using objective criteria and reproducible techniques. Methods: Responses on the 18-item CHFS were obtained from English-speaking patients enrolled in the Scleroderma Patient-Centered Intervention Network Cohort. CHFS unidimensionality was verified using confirmatory factor analysis, and an item response theory model was fit to CHFS items. Optimal test assembly (OTA) methods identified a maximally precise short form for each possible form length between 1 and 17 items. The final short form selected was the form with the least number of items that maintained statistically equivalent convergent validity, compared to the full-length CHFS, with the Health Assessment Questionnaire (HAQ) disability index (DI) and the physical function domain of the 29-item Patient-Reported Outcomes Measurement Information System (PROMIS-29). Results: There were 601 patients included. A 6-item short form of the CHFS (CHFS-6) was selected. The CHFS-6 had a Cronbach's alpha of 0.93. Correlations of the CHFS-6 summed score with HAQ DI (r = 0.79) and PROMIS-29 physical function (r = −0.54) were statistically equivalent to the CHFS (r = 0.81 and r = −0.56). The correlation with the full CHFS was high (r = 0.98). Conclusion: The OTA procedure generated a valid short form of the CHFS with minimal loss of information compared to the full-length form. The OTA method used was based on objective, prespecified criteria, but should be further studied for viability as a general procedure for shortening patient-reported outcome measures in health research.

Original languageEnglish (US)
Pages (from-to)1704-1713
Number of pages10
JournalArthritis and Rheumatism
Volume68
Issue number11
DOIs
StatePublished - Nov 1 2016

ASJC Scopus subject areas

  • Rheumatology

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    Levis, A. W., Harel, D., Kwakkenbos, L., Carrier, M. E., Mouthon, L., Poiraudeau, S., Bartlett, S. J., Khanna, D., Malcarne, V. L., Sauve, M., van den Ende, C. H. M., Poole, J. L., Schouffoer, A. A., Welling, J., Thombs, B. D., Baron, M., Ells, C., Jang, Y., Steele, R. J., ... and the Scleroderma Patient-Centered Intervention Network Investigators (2016). Using Optimal Test Assembly Methods for Shortening Patient-Reported Outcome Measures: Development and Validation of the Cochin Hand Function Scale-6: A Scleroderma Patient-Centered Intervention Network Cohort Study. Arthritis and Rheumatism, 68(11), 1704-1713. https://doi.org/10.1002/acr.22893