Vascular endothelial growth factor in normal human salivary glands and saliva: A possible role in the maintenance of mucosal homeostasis

Norton S. Taichman, Alan T. Cruchley, Laura M. Fletcher, Eleni P. Hagi-Pavli, Ewa M. Paleolog, William R. Abrams, Veronica Booth, Rhodri M. Edwards, Daniel Malamud

Research output: Contribution to journalArticle

Abstract

Saliva is an enriched milieu containing biologically active proteins, including several different growth factors and cytokines. This study documents that vascular endothelial growth factor (VEGF), a potent, multifunctional, angiogenic cytokine, is a component of normal human saliva. VEGF was measured by ELISA in whole saliva (median concentration, 460 pg/ml) and in ductal secretions obtained from the parotid (277 pg/ml) and the submandibular-sublingual (80 pg/ml) salivary glands. VEGF seems to be synthesized endogenously by the salivary glands because both VEGF mRNA and protein (as revealed by in situ reverse transcriptase-PCR and by immunohistochemistry, respectively) colocalized to serous acinar cells and ductal epithelial cells within the parotid, submandibular, and minor salivary glands. These findings point to the existence of a 'salivary VEGF system.' It is possible that salivary VEGF plays a role in regulating physiologic and pathologic angiogenic and other vascular responses in salivary and mucosal tissues. And in particular, the presence of VEGF in saliva may contribute to the remarkable healing capacity of the oral mucosa as well as other regions of the digestive tract.

Original languageEnglish (US)
Pages (from-to)869-875
Number of pages7
JournalLaboratory Investigation
Volume78
Issue number7
StatePublished - Jul 1 1998

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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    Taichman, N. S., Cruchley, A. T., Fletcher, L. M., Hagi-Pavli, E. P., Paleolog, E. M., Abrams, W. R., Booth, V., Edwards, R. M., & Malamud, D. (1998). Vascular endothelial growth factor in normal human salivary glands and saliva: A possible role in the maintenance of mucosal homeostasis. Laboratory Investigation, 78(7), 869-875.