Vasomotor and other menopause symptoms and the prevalence of ideal cardiovascular health metrics among premenopausal stage women

Hye Rin Choi; Yoosoo Chang; Yejin Kim; Yoosun Cho; Min Jung Kwon; Jeonggyu Kang; Ria Kwon; Ga Young Lim; Kye Hyun Kim; Hoon Kim; Yun Soo Hong; Jihwan Park; Di Zhao; Juhee Cho; Eliseo Guallar; Hyun Young Park; Seungho Ryu

doi:10.1097/GME.0000000000002203

Vasomotor and other menopause symptoms and the prevalence of ideal cardiovascular health metrics among premenopausal stage women

Hye Rin Choi, Yoosoo Chang, Yejin Kim, Yoosun Cho, Min Jung Kwon, Jeonggyu Kang, Ria Kwon, Ga Young Lim, Kye Hyun Kim, Hoon Kim, Yun Soo Hong, Jihwan Park, Di Zhao, Juhee Cho, Eliseo Guallar, Hyun Young Park, Seungho Ryu

Global Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Objective We examined the association between menopause symptoms and the prevalence of ideal cardiovascular health (CVH) metrics among premenopausal women. Methods This cross-sectional study comprised 4,611 premenopausal women aged 42 to 52 years. Data for CVH metrics were collected during health screening examinations. Menopause symptoms were measured using the Korean version of the Menopause-Specific Quality of Life questionnaire. For vasomotor, psychosocial, physical, and sexual symptoms, participants were divided into absent or symptomatic groups, further divided into tertiles (range, 0-7; 7 being the most bothersome). Ideal CVH metrics were defined according to the American Heart Association Life Simple 7 metrics, except dietary component. Cardiovascular health metrics were scored from 0 (unhealthy) to 6 (healthy) and classified as poor (0-2), intermediate (3-4), and ideal (5-6). Multinomial logistic regression models were used to estimate the prevalence ratios for intermediate and poor CVH metrics using ideal CVH as the reference. Results The overall and 4 menopause-specific quality of life domain scores were significantly associated with poorer CVH metrics scores in a dose-response manner (P < 0.05). After adjusting for age, parity, education level, anti-Mullerian hormone levels, and alcohol intake, women with the most bothersome degree for vasomotor, psychosocial, physical, and sexual symptoms had significantly higher prevalence of poor CVH metrics, with corresponding prevalence ratios (95% confidence interval) of 2.90 (1.95-4.31), 2.07 (1.36-3.15), 3.01 (1.19-7.65), and 1.66 (1.15-2.39), respectively, compared with those without each vasomotor, psychosocial, physical, and sexual symptom. Conclusions Premenopausal stage women with either vasomotor or nonvasomotor menopausal symptoms have significantly higher prevalence of poor CVH metrics, compared with those without any menopausal symptoms.

Original language	English (US)
Pages (from-to)	750-757
Number of pages	8
Journal	Menopause
Volume	30
Issue number	7
DOIs	https://doi.org/10.1097/GME.0000000000002203
State	Published - Jul 1 2023

Keywords

Climacteric women
Ideal cardiovascular health metrics
Menopause symptoms
Premenopausal stage
STRAW-10
Vasomotor symptoms

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1097/GME.0000000000002203

Cite this

Choi, H. R., Chang, Y., Kim, Y., Cho, Y., Kwon, M. J., Kang, J., Kwon, R., Lim, G. Y., Kim, K. H., Kim, H., Hong, Y. S., Park, J., Zhao, D., Cho, J., Guallar, E., Park, H. Y., & Ryu, S. (2023). Vasomotor and other menopause symptoms and the prevalence of ideal cardiovascular health metrics among premenopausal stage women. Menopause, 30(7), 750-757. https://doi.org/10.1097/GME.0000000000002203

Choi, HR, Chang, Y, Kim, Y, Cho, Y, Kwon, MJ, Kang, J, Kwon, R, Lim, GY, Kim, KH, Kim, H, Hong, YS, Park, J, Zhao, D, Cho, J, Guallar, E, Park, HY & Ryu, S 2023, 'Vasomotor and other menopause symptoms and the prevalence of ideal cardiovascular health metrics among premenopausal stage women', Menopause, vol. 30, no. 7, pp. 750-757. https://doi.org/10.1097/GME.0000000000002203

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abstract = "Objective We examined the association between menopause symptoms and the prevalence of ideal cardiovascular health (CVH) metrics among premenopausal women. Methods This cross-sectional study comprised 4,611 premenopausal women aged 42 to 52 years. Data for CVH metrics were collected during health screening examinations. Menopause symptoms were measured using the Korean version of the Menopause-Specific Quality of Life questionnaire. For vasomotor, psychosocial, physical, and sexual symptoms, participants were divided into absent or symptomatic groups, further divided into tertiles (range, 0-7; 7 being the most bothersome). Ideal CVH metrics were defined according to the American Heart Association Life Simple 7 metrics, except dietary component. Cardiovascular health metrics were scored from 0 (unhealthy) to 6 (healthy) and classified as poor (0-2), intermediate (3-4), and ideal (5-6). Multinomial logistic regression models were used to estimate the prevalence ratios for intermediate and poor CVH metrics using ideal CVH as the reference. Results The overall and 4 menopause-specific quality of life domain scores were significantly associated with poorer CVH metrics scores in a dose-response manner (P < 0.05). After adjusting for age, parity, education level, anti-Mullerian hormone levels, and alcohol intake, women with the most bothersome degree for vasomotor, psychosocial, physical, and sexual symptoms had significantly higher prevalence of poor CVH metrics, with corresponding prevalence ratios (95% confidence interval) of 2.90 (1.95-4.31), 2.07 (1.36-3.15), 3.01 (1.19-7.65), and 1.66 (1.15-2.39), respectively, compared with those without each vasomotor, psychosocial, physical, and sexual symptom. Conclusions Premenopausal stage women with either vasomotor or nonvasomotor menopausal symptoms have significantly higher prevalence of poor CVH metrics, compared with those without any menopausal symptoms.",

keywords = "Climacteric women, Ideal cardiovascular health metrics, Menopause symptoms, Premenopausal stage, STRAW-10, Vasomotor symptoms",

author = "Choi, {Hye Rin} and Yoosoo Chang and Yejin Kim and Yoosun Cho and Kwon, {Min Jung} and Jeonggyu Kang and Ria Kwon and Lim, {Ga Young} and Kim, {Kye Hyun} and Hoon Kim and Hong, {Yun Soo} and Jihwan Park and Di Zhao and Juhee Cho and Eliseo Guallar and Park, {Hyun Young} and Seungho Ryu",

year = "2023",

month = jul,

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doi = "10.1097/GME.0000000000002203",

language = "English (US)",

volume = "30",

pages = "750--757",

journal = "Menopause",

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TY - JOUR

T1 - Vasomotor and other menopause symptoms and the prevalence of ideal cardiovascular health metrics among premenopausal stage women

AU - Choi, Hye Rin

AU - Chang, Yoosoo

AU - Kim, Yejin

AU - Cho, Yoosun

AU - Kwon, Min Jung

AU - Kang, Jeonggyu

AU - Kwon, Ria

AU - Lim, Ga Young

AU - Kim, Kye Hyun

AU - Kim, Hoon

AU - Hong, Yun Soo

AU - Park, Jihwan

AU - Zhao, Di

AU - Cho, Juhee

AU - Guallar, Eliseo

AU - Park, Hyun Young

AU - Ryu, Seungho

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Objective We examined the association between menopause symptoms and the prevalence of ideal cardiovascular health (CVH) metrics among premenopausal women. Methods This cross-sectional study comprised 4,611 premenopausal women aged 42 to 52 years. Data for CVH metrics were collected during health screening examinations. Menopause symptoms were measured using the Korean version of the Menopause-Specific Quality of Life questionnaire. For vasomotor, psychosocial, physical, and sexual symptoms, participants were divided into absent or symptomatic groups, further divided into tertiles (range, 0-7; 7 being the most bothersome). Ideal CVH metrics were defined according to the American Heart Association Life Simple 7 metrics, except dietary component. Cardiovascular health metrics were scored from 0 (unhealthy) to 6 (healthy) and classified as poor (0-2), intermediate (3-4), and ideal (5-6). Multinomial logistic regression models were used to estimate the prevalence ratios for intermediate and poor CVH metrics using ideal CVH as the reference. Results The overall and 4 menopause-specific quality of life domain scores were significantly associated with poorer CVH metrics scores in a dose-response manner (P < 0.05). After adjusting for age, parity, education level, anti-Mullerian hormone levels, and alcohol intake, women with the most bothersome degree for vasomotor, psychosocial, physical, and sexual symptoms had significantly higher prevalence of poor CVH metrics, with corresponding prevalence ratios (95% confidence interval) of 2.90 (1.95-4.31), 2.07 (1.36-3.15), 3.01 (1.19-7.65), and 1.66 (1.15-2.39), respectively, compared with those without each vasomotor, psychosocial, physical, and sexual symptom. Conclusions Premenopausal stage women with either vasomotor or nonvasomotor menopausal symptoms have significantly higher prevalence of poor CVH metrics, compared with those without any menopausal symptoms.

AB - Objective We examined the association between menopause symptoms and the prevalence of ideal cardiovascular health (CVH) metrics among premenopausal women. Methods This cross-sectional study comprised 4,611 premenopausal women aged 42 to 52 years. Data for CVH metrics were collected during health screening examinations. Menopause symptoms were measured using the Korean version of the Menopause-Specific Quality of Life questionnaire. For vasomotor, psychosocial, physical, and sexual symptoms, participants were divided into absent or symptomatic groups, further divided into tertiles (range, 0-7; 7 being the most bothersome). Ideal CVH metrics were defined according to the American Heart Association Life Simple 7 metrics, except dietary component. Cardiovascular health metrics were scored from 0 (unhealthy) to 6 (healthy) and classified as poor (0-2), intermediate (3-4), and ideal (5-6). Multinomial logistic regression models were used to estimate the prevalence ratios for intermediate and poor CVH metrics using ideal CVH as the reference. Results The overall and 4 menopause-specific quality of life domain scores were significantly associated with poorer CVH metrics scores in a dose-response manner (P < 0.05). After adjusting for age, parity, education level, anti-Mullerian hormone levels, and alcohol intake, women with the most bothersome degree for vasomotor, psychosocial, physical, and sexual symptoms had significantly higher prevalence of poor CVH metrics, with corresponding prevalence ratios (95% confidence interval) of 2.90 (1.95-4.31), 2.07 (1.36-3.15), 3.01 (1.19-7.65), and 1.66 (1.15-2.39), respectively, compared with those without each vasomotor, psychosocial, physical, and sexual symptom. Conclusions Premenopausal stage women with either vasomotor or nonvasomotor menopausal symptoms have significantly higher prevalence of poor CVH metrics, compared with those without any menopausal symptoms.

KW - Climacteric women

KW - Ideal cardiovascular health metrics

KW - Menopause symptoms

KW - Premenopausal stage

KW - STRAW-10

KW - Vasomotor symptoms

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JO - Menopause

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ER -

Vasomotor and other menopause symptoms and the prevalence of ideal cardiovascular health metrics among premenopausal stage women

Abstract

Keywords

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